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Table 2 Characteristics of the included studies

From: Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review

  First author, year of publication Country Study design Topical agent Diagnostic method Number of patients (per protocol) Disease
1 Sidhu, 1997 [14] Ireland (UK) RCT 5-FU Biopsy 94 CIN 1–2
2 Rahangdale, 2014 [13] USA RCT 5-FU Biopsy 55 CIN 2 (3)
3 Meyskens, 1994 [28] USA RCT atRA Biopsy 232 CIN 2–3
4 Ruffin, 2004 [29] USA RCT atRA Biopsy 174 CIN 2–3
5 Van Pachterbeke, 2009 [16] Belgium RCT Cidofovir Biopsy 48 CIN 2–3
6 Grimm, 2012 [30] Austria RCT Imiquimod Biopsy 55 CIN 2–3
  1. CIN cervical intraepithelial neoplasian, CT clinical trial, FU fluorouracil, HPV HPV infection, atRA all-trans retinoic acid, RCT randomized clinical trial, UK United Kingdom, USA United States of America