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Table 2 Data extraction form

From: Immunotherapy with check-point inhibitors (CPI) in adult malignancies: a protocol for the systematic review of the quality of economic analyses

Variable name

Allowable values

Explanation

Baseline trial characteristics

ID

Valid PubMed ID number

Pubmed ID

Journal

Name of journal

Journal of publication

Year

2007–2018

Year of publication

Tumor site

Non-small cell lung cancer Melanoma Renal cell carcinoma Squamous cell carcinoma of the head and neck Urothelial carcinoma Classical Hodgkin lymphoma Other

The tumor type for which treatment with a check-point inhibitor was analyzed.

Check_point_1

Nivolumab

Name of the first check-point inhibitor being compared.

Pembrolizumab

Atezolizumab

Avelumab

Durvalumab

Ipilimumab

Tremelimumab

Check_point_2

Nivolumab

Name of 2nd check-point inhibitor being compared, if applicable.

Pembrolizumab

Atezolizumab

Avelumab

Durvalumab

Ipilimumab

Tremelimumab

Comparator_1

Placebo

Name of the 1st non-check-point-inhibitor agent or chemotherapeutic regimen being compared, if applicable.

Name of other agent or regimen

Comparator_2

Placebo

Name of the 2nd non-check-point-inhibitor agent or chemotherapeutic regimen being compared, if applicable.

Name of other agent or regimen

Funding

Industry/government

Funding source declared by article

Country

List of country names

List of all the countries in which the economic analysis applied as reported by the article.

Multiple_countries

Y/N

Did the economic analysis apply to multiple countries?

CHEERS criteria

Title

C/I

As detailed in CHEERS recommendations [9]

Abstract

C/PC/I

As detailed in CHEERS recommendations [9]

Background & Objectives

C/PC/I

As detailed in CHEERS recommendations [9]

Target population

C/PC/I

As detailed in CHEERS recommendations [9]

Setting_Location

C/PC/I

As detailed in CHEERS recommendations [9]

Perspective

C/PC/I

As detailed in CHEERS recommendations [9]

Comparators

C/PC/I

As detailed in CHEERS recommendations [9]

Time horizon

C/PC/I

As detailed in CHEERS recommendations [9]

Discount rate

C/PC/I

As detailed in CHEERS recommendations [9]

Health outcomes

C/PC/I

As detailed in CHEERS recommendations [9]

Effectiveness

C/PC/I

As detailed in CHEERS recommendations [9]

Preference for outcomes

C/PC/I/NA

As detailed in CHEERS recommendations [9]

Resources and cost

C/PC/I

As detailed in CHEERS recommendations [9]

Resource quantities

C/PC/I

As detailed in CHEERS recommendations [9]

Choice of model

C/PC/I

As detailed in CHEERS recommendations [9]

Assumptions

C/PC/I

As detailed in CHEERS recommendations [9]

Analytic methods

C/PC/I

As detailed in CHEERS recommendations [9]

Study parameters

C/PC/I

As detailed in CHEERS recommendations [9]

ICERs

C/PC/I

As detailed in CHEERS recommendations [9]

Uncertainty

C/PC/I

As detailed in CHEERS recommendations [9]

Heterogeneity

C/PC/I/NA

As detailed in CHEERS recommendations [9]

Limitations

C/PC/I

As detailed in CHEERS recommendations [9]

Funding source

C/I

As detailed in CHEERS recommendations [9]

Conflict of Interest

C/I

As detailed in CHEERS recommendations [9]

  1. C complete; PC partially complete; I incomplete; NA not applicable