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Table 6 Included reviews

From: Risk of bias judgements and strength of conclusions in meta-evidence from the Cochrane Colorectal Cancer Group

Review

Year

Author

Intervention

Conclusion

Abdominal drainage to prevent intra-peritoneal abscess after open appendectomy for complicated appendicitis

2015

Nelson RL, et al.

Surgical

N-F

Adjuvant chemotherapy for small intestine adenocarcinoma

2007

Singhal N, Singhal D

Medical

N-F

Adjuvant Therapy for completely resected Stage II Colon Cancer

2008

Figueredo A, et al.

Medical & Surgical

I-T

Analgesia in patients with acute abdominal pain

2011

Manterola C, et al.

Medical

I-F

Anti-angiogenic therapies for metastatic colorectal cancer

2009

Wagner ADADW, et al.

Medical

I-F

Antibiotic prophylaxis for hernia repair.

2012

Sanchez-Manuel FJ, et al.

Medical & Surgical

N-T

Antibiotic regimens for secondary peritonitis of gastrointestinal origin in adults

2005

Wong PF, et al.

Medical

I-F

Antibiotics for uncomplicated diverticulitis

2012

Shabanzadeh DM, Wille-Jørgensen P

Medical

N-T

Antibiotics versus placebo for prevention of postoperative infection after appendicectomy.

2005

BR Andersen, et al.

Medical & Surgical

I-F

Antimicrobial prophylaxis for colorectal surgery

2014

Nelson RL, et al.

Medical & Surgical

I-F

Appendectomy versus antibiotic treatment for acute appendicitis

2011

Wilms IMHA, et al.

Medical & Surgical

I-T

Cesarean delivery for the prevention of anal incontinence

2010

Nelson RL, et al.

Surgical

I-F

Chewing gum for postoperative recovery of gastrointestinal function

2015

Short V, et al.

Surgical

N-T

Cisapride for Intestinal Constipation

2009

Aboumarzouk OM, et al.

Medical

I-F

Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications

2017

Patel SV, et al.

Surgical

I-T

Closure methods of the appendix stump for complications during laparoscopic appendectomy

2017

Mannu GS, et al.

Surgical

N-F

Colorectal stents for the management of malignant colonic obstructions

2011

Sagar J

Surgical

I-T

Combination chemotherapy versus single-agent chemotherapy during preoperative chemoradiation for resectable rectal cancer

2015

Resende HM, et al.

Medical & Surgical

N-F

Conventional versus LigaSure hemorrhoidectomy for patients with symptomatic Hemorrhoids

2009

Nienhuijs SW, et al.

Surgical

I-T

Covering ileo- or colostomy in anterior resection for rectal carcinoma

2010

Montedori A, et al.

Surgical

I-T

Curative surgery for obstruction from primary left colorectal carcinoma- Primary or staged resection?

2004

De Salvo GL, et al.

Surgical

N-F

Daikenchuto for reducing postoperative ileus in patients undergoing elective abdominal surgery

2018

Hoshino N, et al.

Medical & Surgical

N-F

Duration of adjuvant chemotherapy for patients with non-metastatic colorectal cancer

2010

Des Guetz G, et al.

Medical

I-F

Early enteral nutrition within 24 h of colorectal surgery versus later commencement of feeding for postoperative complications

2006

Andersen HK, et al.

Surgical

N-T

Early versus delayed appendicectomy for appendiceal phlegmon or abscess

2017

Cheng Y, et al.

Surgical

N-F

Energy source instruments for laparoscopic colectomy

2011

Tou S, et al.

Surgical

N-F

Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer

2017

Chan DLH, et al.

Medical

I-F

Epidural local anesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery

2016

Guay J, et al.

Medical & Surgical

I-F

Fast track surgery versus conventional recovery strategies for colorectal surgery

2011

Spanjersberg WR, et al.

Surgical

N-T

Fluoropyrimidine-HAI (hepatic arterial infusion) versus systemic chemotherapy (SCT) for unresectable liver metastases from colorectal cancer

2009

Mocellin S, et al.

Medical

I-F

Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery

2013

Cheng Y, et al.

Surgical

N-T

Hand assisted laparoscopic surgery versus conventional laparoscopy for colorectal surgery

2010

Spanjersberg WR, et al.

Surgical

I-T

Heated insufflation with or without humidification for laparoscopic abdominal surgery

2016

Birch DW, et al.

Surgical

I-F

Heparins and mechanical methods for thromboprophylaxis in colorectal surgery

2004

Wille-Jørgensen P, et al.

Medical & Surgical

I-F

Hepatic artery adjuvant chemotherapy for patients having resection or ablation of colorectal cancer metastatic to the liver

2006

Nelson RL, Freels S

Medical & Surgical

N-T

Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer

2012

Deva S, Jameson M

Medical

I-T

Ileostomy or colostomy for temporary decompression of colorectal anastomosis

2007

Güenaga KF, et al.

Surgical

N-T

Incision and drainage of perianal abscess with or without treatment of anal fistula

2010

Malik AI, et al.

Surgical

I-F

Interventions for anal canal intraepithelial neoplasia

2012

Macaya A, et al.

Surgical

N-F

Intra-abdominal drains for the prophylaxis of anastomotic leak in elective colorectal surgery

2004

Rolph R, et al.

Surgical

N-F

Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynecological abdominal surgery

2009

Kumar S, et al.

Medical & Surgical

N-T

Irinotecan chemotherapy combined with fluoropyrimidines versus irinotecan alone for overall survival and progression-free survival in patients with advanced and/or metastatic colorectal cancer

2016

Wulaningsih W, et al.

Medical

N-F

Lactulose versus Polyethylene Glycol for Chronic Constipation

2010

Lee-Robichaud H, et al.

Medical

I-F

Laparoscopic techniques versus open techniques for inguinal hernia repair

2003

Willaert W, et al.

Surgical

I-T

Laparoscopic versus open resection for sigmoid diverticulitis

2017

Abraha I, et al.

Surgical

N-F

Laparoscopic versus open surgery for small bowel Crohn’s disease

2011

Dasari BVM, et al.

Surgical

I-T

Laparoscopic versus open surgery in small bowel obstruction

2010

Cirocchi R, et al.

Surgical

N-F

Laparoscopic versus open surgery for suspected appendicitis

2010

Sauerland S, et al.

Surgical

I-T

Laparoscopic versus open surgical techniques for ventral or incisional hernia repair

2011

Sauerland S, et al.

Surgical

N-T

Laparoscopic versus open total mesorectal excision for rectal cancer

2014

S Vennix, et al.

Surgical

I-T

Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation

2013

Hardt J, et al.

Surgical

N-F

Laxatives for the treatment of hemorrhoids.

2005

Alonso-Coello P, et al.

Medical

I-F

Long-term results of laparoscopic colorectal cancer resection

2008

E Kuhry, et al.

Surgical

I-T

Management for intussusception in children

2017

Gluckman S, et al.

Medical & Surgical

N-T

Mechanical bowel preparation for elective colorectal surgery

2011

Güenaga KF, et al.

Surgical

N-T

Mesalamine (5-ASA) for the prevention of recurrent diverticulitis

2017

Carter F, et al.

Medical

N-F

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty

2017

Sun P, et al.

Surgical

I-T

Nitrous Oxide for Colonoscopy

2011

Aboumarzouk OM, et al.

Surgical

I-T

Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas

2004

Asano TK, McLeod RS

Medical

I-F

Nonsurgical therapy for anal fissure

2012

Nelson RL, et al.

Medical

I-F

Non-resection versus resection for an asymptomatic primary tumor in patients with unresectable Stage IV colorectal cancer

2012

Cirocchi R, et al.

Medical & Surgical

I-T

Open Mesh versus non-Mesh for groin hernia repair

2001

Scott N, et al.

Surgical

I-T

Open Preperitoneal Techniques versus Lichtenstein Repair for elective Inguinal Hernias

2012

Willaert W, et al.

Surgical

I-F

Open surgical procedures for incisional hernias

2008

D den Hartog, et al.

Surgical

N-F

Open versus laparoscopic (assisted) ileo pouch anal anastomosis for ulcerative colitis and familial adenomatous polyposis

2009

Ahmed Ali U, et al.

Surgical

I-T

Operative procedures for fissure in ano

2001

Nelson RL, et al.

Surgical

I-T

Oral versus intravenous fluoropyrimidines for colorectal cancer

2017

Chionh F, et al.

Medical

I-F

Oral water soluble contrast for the management of adhesive small bowel obstruction

2007

Abbas S, et al.

Medical

I-F

Palliative chemotherapy for advanced or metastatic colorectal cancer

2000

Best L, et al.

Medical

I-F

Phlebotonics for hemorrhoids

2012

Perera N, et al.

Medical

I-T

Postoperative adjuvant chemotherapy in rectal cancer operated for cure.

2012

Petersen SH, et al.

Medical & Surgical

I-F

Pre and peri-operative erythropoeitin for reducing allogeneic blood transfusions in colorectal cancer surgery.

2009

Devon KM, McLeod RS

Medical & Surgical

N-F

Pre-operative chemoradiation for non-metastatic locally advanced rectal cancer

2012

McCarthy K, et al.

Medical & Surgical

I-T

Pre-operative Nutrition Support in Patients Undergoing Gastrointestinal Surgery.

2012

Burden S, et al.

Surgical

N-T

Prolonged thromboprophylaxis with Low Molecular Weight heparin for abdominal or pelvic surgery

2009

Rasmussen MS, et al.

Medical & Surgical

I-F

Prophylactic nasogastric decompression after abdominal surgery

2007

Verma R, Nelson RL

Surgical

I-F

Propofol for sedation during colonoscopy

2008

Singh H, et al.

Medical & Surgical

I-T

Prosthetic mesh placement for the prevention of parastomal herniation

2018

Jones HG, et al.

Surgical

I-T

Quality of life after rectal resection for cancer, with or without permanent colostomy.

2010

Pachler J, Wille-Jørgensen P

Surgical

N-T

Reconstructive Techniques After Rectal Resection for Rectal Cancer

2008

Brown CJ, et al.

Surgical

I-F

Resection versus no intervention or other surgical interventions for colorectal cancer liver metastases

2007

Fedorowicz Z, et al.

Medical & Surgical

N-T

Rubber band ligation versus excisional haemorrhoidectomy for hemorrhoids

2005

Shanmugam V, et al.

Surgical

I-T

Second-line systemic therapy for metastatic colorectal cancer

2017

Mocellin S, et al.

Medical

I-F

Short term benefits for laparoscopic colorectal resection

2005

Schwenk W, et al.

Surgical

I-F

Shouldice technique versus other open techniques for inguinal hernia repair

2012

Amato B, et al.

Surgical

I-T

Single incision versus conventional multi-incision appendicectomy for suspected appendicitis

2011

Rehman H, et al.

Surgical

N-F

Single layer versus double layer suture anastomosis of the gastrointestinal tract

2012

Sajid MS, et al.

Surgical

I-T

Stapled versus conventional surgery for hemorrhoids

2006

Lumb KJ, et al.

Surgical

I-F

Stapled versus handsewn methods for colorectal anastomosis surgery

2001

Matos D, et al.

Surgical

I-F

Stapled versus handsewn methods for ileocolic anastomoses

2011

Choy PYG, et al.

Surgical

I-F

Surgical intervention for anorectal fistula

2010

Jacob TJ, et al.

Surgical

N-T

Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults

2008

Traut U, et al.

Medical & Surgical

N-T

Transabdominal pre-peritoneal (TAPP) vs totally extraperitoneal (TEP) laparoscopic techniques for inguinal hernia repair.

2005

Wake BL, et al.

Surgical

N-F

Transverse verses midline incisions for abdominal surgery

2005

Brown SR, et al.

Surgical

N-T

Water infusion versus air insufflation for colonoscopy

2015

Hafner S, et al.

Surgical

I-T

  1. I-F informs clinical practicefirm, I-T informs clinical practicetempered, N-T does not inform clinical practicetempered, N-F does not inform clinical practicefirm