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Table 2 League table presenting the results with difference in restricted mean survival time (in months) of the network meta-analysis (random effects, lower triangle) and of the conventional meta-analysis (random effects, upper triangle) for overall survival at t* = 10 years

From: Individual patient data network meta-analysis using either restricted mean survival time difference or hazard ratios: is there a difference? A case study on locoregionally advanced nasopharyngeal carcinomas

  1. I2 = 14.7%, heterogeneity (within design) p = 0.29, inconsistency (between designs) p = 0.33. Individual trial (comparison) rmstD are given in Table 1. As a convention, the cells contain the difference in restricted mean survival time in months (rmstD; 95% confidence interval) of the treatment with the higher number compared to the treatment with the lower number. For example, the cell that joins treatments 4 (CRT) and 5 (CRT-AC) gives the rmstD of treatment 5 vs. 4 (CRT-AC vs. CRT)
  2. Same direction of treatment effect but difference in significance between HR and rmstD
  3. Different direction of treatment effect but both HR and rmstD are not significant
  4. AC adjuvant chemotherapy, CRT concomitant chemoradiotherapy, HR hazard ratio, IC induction chemotherapy, rmstD restricted mean survival time difference, RT radiotherapy
  5. *Comparison with only one trial