Table 3 Benefits and harms of the HPV vaccines: characteristics of included participants
Characteristics of included participantsa | Total | HPV vaccine | Comparator | ||||||
|---|---|---|---|---|---|---|---|---|---|
HPV vaccine (N = 47,075) | Comparator (N = 48,595) | Cervarix (N = 31,316) | Gardasil (N = 13,937) | Gardasil 9 (N = 618) | HPV 16 vaccine (N = 1204) | Placebo (N = 306) | Adjuvantb (N = 18,789) | Hepatitis vaccinec (N = 29,500) | |
Participation | |||||||||
Randomised | 47,075 | 48,595 | 31,316 | 13,937 | 618 | 1204 | 306 | 18,789 | 29,500 |
Received one (1) dose | 47,012 (99%) | 48,556 (99%) | 31,291 (99%) | 13,927 (99%) | 615 (99%) | 1193 (99%) | 306 (100%) | 18,750 (99%) | 29,500 (100%) |
Received two (2) doses | 46,105 (98%) | 47,725 (98%) | 30,788 (98%) | 13,564 (97%) | 604 (98%) | 1092 (91%) | 304 (99%) | 18,304 (97%) | 29,117 (99%) |
Received three (3) doses | 45,079 (96%) | 46,726 (96%) | 30,073 (96%) | 13,286 (95%) | 597 (97%) | 1019 (85%) | 300 (98%) | 17,906 (96%) | 28,520 (97%) |
Completed vaccination period | 44,202 (94%) | 45,862 (94%) | 29,331 (94%) | 13,156 (94%) | 595 (97%) | 993 (82%) | 300 (98%) | 17,809 (95%) | 27,753 (94%) |
Entered follow-up period | 18,540 (39%) | 18,059 (37%) | 4090 (14%) | 13,344 (96%) | Not applicable | 1126 (94%) | Not applicable | 17,590 (94%) | 469 (2%) |
Completed follow-up period | 15,826 (34%) | 14,601 (30%) | 2929 (10%) | 11,986 (86%) | Not applicable | 835 (69%) | Not applicable | 14,445 (77%) | 156 (1%) |
Gender | |||||||||
Female | 42,036 (89%) | 37,066 (76%) | 28,876 (92%) | 11,338 (81%) | 618 (100%) | 1204 (100%) | 306 (100%) | 16,481 (88%) | 20,279 (69%) |
Age | |||||||||
Mean age in years | 20.3 | 20.2 | 21.2 | 21.4 | 19.0 | 20.0 | 19.0 | 22.9 | 20.5 |
Age group range in years | 9–72 | 8–68 | 9–72 | 9–45 | 12–26 | 16–25 | 12–26 | 9–68 | 8–46 |
Race | |||||||||
Asian | 7589 (16%) | 7295 (15%) | 6232 (20%) | 1248 (9%) | 40 (6%) | 69 (6%) | 14 (5%) | 2678 (14%) | 4603 (16%) |
Black | 1426 (3%) | 1492 (3%) | 467 (2%) | 862 (6%) | 3 (1%) | 94 (8%) | 3 (1%) | 1108 (6%) | 381 (1%) |
Hispanic | 4492 (10%) | 4378 (9%) | 1787 (6%) | 2616 (19%) | 0 (0%) | 89 (7%) | 0 (0%) | 3403 (18%) | 975 (3%) |
White | 31,743 (67%) | 33,558 (69%) | 22,335 (70%) | 7998 (56%) | 483 (78%) | 918 (76%) | 231 (75%) | 9960 (53%) | 23,367 (79%) |
Other | 1625 (3%) | 1576 (3%) | 297 (1%) | 1202 (9%) | 92 (15%) | 34 (3%) | 58 (19%) | 1343 (7%) | 174 (1%) |
Unknown | 209 (1%) | 296 (1%) | 198 (1%) | 11 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 297 (2%) | 0 (0%) |