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Table 2 Table of critical confounders developed for a systematic review of studies assessing the association of dairy intake with cardiovascular outcomes

From: The risk of bias in observational studies of exposures (ROBINS-E) tool: concerns arising from application to observational studies of exposures

Outcome

Confounders (p/h)

Confounders (all outcomes)

1. CVD mortality

Fibre supplement (p)

Red meat (h)

Sodium (Na+) (h)

Age

Sex

BMI

Smoking

Alcohol intake

History of co-morbidities

Parenteral/Fhx MI < 60 years

PA levels

SES

Total energy intake

Fruit and vegetable intake

Specialised confounders

Hormone therapy

2. CVD events

Fibre supplement (p)

Magnesium supplement (p)

3. CHD mortality

Fibre supplement (p)

Trans fat (h)

Polyunsaturated fat (n-6) (p)

Sodium (+Na) (h)

4. CHD events

Fibre supplement (p)

Trans fat (h)

Magnesium supplement (p)

Polyunsaturated fat (n-6) (p)

5. Total MI

Aspirin (p)

Vitamin E supplement (p)

6. Fatal MI

Vitamin E supplement (p)

7. Non-fatal MI

Aspirin (p)

8. Total stroke

Potassium supplement (p)

Red meat (h)

Sodium (+Na) (h)

9. Ischemic stroke

Aspirin (p)

Polyunsaturated fat (LC n-3) (p)

Red meat (h)

10. Haemorrhagic stroke

Aspirin (h)

  1. p protective, h harmfulÂ