Table 5 Summary of mortality outcome for transfusion interventions for a significant difference in mortality
From: Anesthesia interventions that alter perioperative mortality: a scoping review
First author, year | Type of surgery, no. of participants | Intervention/comparison details | Perioperative phase, duration of intervention | Impact on mortality* (outcome definition, timing) |
|---|---|---|---|---|
Bilgin, 2004 | Cardiac, 474 | Leuko-depleted red blood cell transfusion. Platelet concentrates were prepared from pooled buffy coats and were all leukocyte-depleted by filtration (< 1 × 106 leukocytes per product) before storage. Standard buffy coat-depleted packaged cells. | Intraoperative During most of the intraoperative phase | Decreased mortality (in-hospital, secondary outcome) |
Foss, 2009 | Orthopedic, 107 | A hemoglobin threshold of 10.0 g/dL (liberal) versus 8.0 g/dL (restrictive) in the entire perioperative period Receive transfusion at a hemoglobin threshold of 8.0 g/dL (restrictive) in the entire perioperative period. | Preoperative, Intraoperative, postoperative During most of the intraoperative phase | Decreased mortality (30-day mortality, secondary outcome) |
Kosmadakis, 2003 | Colorectal, 63 | The intervention involved administration of subcutaneous erythropoietin (r-HuEPO at 300 IU/kg) plus IV iron (100 mg) for 7 days preop, and 7 days postop surgery for gastrointestinal malignancies. Received placebo medication subcutaneously and 100 mg iron intravenously each day. | Preoperative, postoperative Every day for a time period: “erythropoietin or placebo applications were given for 14 days perioperatively, starting 7 days before the operation.” | Decreased mortality (1-year survival, NR) |
Van de Watering, 1998 | Cardiac, 914 | One of the following three trial arms: “(1) the PC trial arm, in which when transfusion was indicated, standard packed cells (PC) without buffy coat were transfused; (2) the prestorage filtration FF trial arm, in which when transfusion was indicated, freshly filtered (i.e., < 24 h after donation) units were transfused; and (3) the poststorage filtration SF trial arm, ill which when transfusion was indicated, 6- to 20-day stored packed cells without buffy coat were filtered shortly before transfusion.” | Intraoperative During most of the intraoperative phase | Decreased mortality (in-hospital, NR) |