Table 2 DERP SRs with changes in findings based on dossier evidence
DERP SR | N and type of evidence* | N unpublished | Fills gaps? (N) | Contradicts other evidence? |
|---|---|---|---|---|
Atypical antipsychotics update 2 | 1 unique study | 0 | No | No |
Atypical antipsychotics update 3 | 23 unique study 3 supplemental data | 20 3 | Yes (19) Yes (3) | No, included in meta-analyses |
Atypical antipsychotics update 4 | 2 unique study 1 supplemental data | 1 0 | Yes (2) Yes (1) | NA |
ADHD update 4 | 1 unique study | No | Yes (1) | NA |
Asthma/COPD | 5 unique study 1 supplemental data | 2 0 | Yes (4) Yes (1) | No, included in meta-analysis |
Combination products | 1 unique study | 0 | Yes (1) | NA |
Diabetes drugs | 2 unique study | 0 | Yes (2) | NA |
Hepatitis C original | 2 unique study | 1 | Yes (2) | NA |
Hepatitis C update 1 | 3 unique study | 1 | Yes (3) | NA |
Long-acting insulins | 4 unique study 2 supplemental data | 0 0 | Yes (3) Yes (2) | Yes, findings in offspring of women using insulin during pregnancy contradict one other study found. |
Multiple sclerosis update 2 | 1 unique study | 0 | No | Yes, contradicted findings of studies with longer duration (favored manufacturers drug in shorter duration, no difference with longer duration) |
Neuropathic pain | 1 unique study | 0 | Yes (1) | NA |
Proton pump inhibitors Update 5 | 6 unique study | 0 | Yes (6) | NA |
Topical calcineurin inhibitors | 3 unique study 1 supplemental data | 1 0 | Yes (2) Yes (1) | NA |
Triptans update 4 | 1 supplemental data | 1 | Yes (1) | NA |