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Table 2 Results from the meta-analysis, pooled survival estimates and heterogeneity statistics

From: Survival estimates stratified by the Nottingham Prognostic Index for early breast cancer: a systematic review and meta-analysis of observational studies

Statistic

NPI 1

NPI 2

NPI 3

5-year follow-up

 Fixed effects I-V estimate (95% CI)

0.953 (0.949, 0.957)

0.831 (0.825, 0.837)

0.535 (0.521, 0.549)

 Random effects D-L estimate (95% CI)

0.943 (0.927, 0.96)

0.811 (0.769, 0.853)

0.565 (0.462, 0.668)

I2 (%)

89.6

97.2

97.7

Q

115.93 (P < 0.001)

422.5 (P < 0.001)

532.32 (P < 0.001)

 Tau (% points)

2.45

7.28

18.25

10-year follow-up

 Fixed effects I-V estimate (95% CI)

0.883 (0.877, 0.888)

0.682 (0.675, 0.689)

0.353 (0.341, 0.364)

 Random effects D-L estimate (95% CI)

0.869 (0.837, 0.901)

0.674 (0.608, 0.74)

0.414 (0.329, 0.499)

I2 (%)

95.3

98.6

97.7

Q

213.56 (P < 0.001)

727.14 (P < 0.001)

427.44 (P < 0.001)

 Tau (% points)

4.58

10.77

13.71

  1. I-V inverse variance, D-L DerSimonian and Laird method