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Table 3 The hierarchy of outcomes to be extracted and included in final data synthesis

From: Blood pressure reduction and clinical outcomes with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: protocol for a systematic review and meta-regression analysis

Outcome Status Rank Explanation
All-cause mortality Primary 1 Total number of deaths in each study group due to any attributed cause.
Myocardial infarction Primary 1 Non-fatal or fatal myocardial infarction, or sudden cardiac death
2 Non-fatal or fatal myocardial infarction
3 Fatal myocardial infarction, or sudden cardiac death
4 Non-fatal myocardial infarction only
5 Fatal myocardial infarction only
6 Any other definition of a myocardial infarction-related endpoint
Cardiovascular mortality Secondary 1 Fatal myocardial infarction, stroke, other cardiovascular disease or sudden death
2 Fatal myocardial infarction, stroke or other cardiovascular disease
3 Fatal myocardial infarction, stroke or sudden death
4 Fatal myocardial infarction or stroke
5 Any other definition of cardiovascular mortality
Stroke Secondary 1 Non-fatal or fatal stroke, not including transient ischaemic attack
2 Fatal stroke
3 Non-fatal stroke
4 Non-fatal stroke or transient ischaemic attack
5 Non-fatal or fatal stroke or transient ischaemic attack
6 Any other definition of a stroke-related endpoint
Revascularisation Secondary 1 Any need for unplanned revascularisation
Heart failure Secondary 1 Management of heart failure, requiring medical attention, hospital attendance or admission
  1. Rank 1 is the preferred outcome definition to be extracted and included in data synthesis. In the event of a study not reporting the first-ranked outcome, and this data not being available from contacting authors and sponsors, the next lowest ranked endpoint reported (or calculable without double-counting) in each study will be included in final data synthesis