Blood pressure reduction and clinical outcomes with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: protocol for a systematic review and meta-regression analysis

Table 1 A summary of the main study elements in PICO format

Study elements	Description
Participants	Patients with an indication for inhibition of the renin-angiotensin aldosterone system, stratified into those with (i) hypertension and (ii) heart failure.
Intervention	Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEis)
Control or comparison	Placebo, or other classes of antihypertensive agent
Outcome	Standardisation will be performed to estimate the effect of a 10 mmHg reduction in blood pressure with each class of drug on the relative risk of each outcome. Primary: myocardial infarction and all-cause mortality Secondary: cardiovascular mortality, stroke, heart failure and revascularization

ISSN: 2046-4053