Fig. 6From: B-type natriuretic peptide-guided therapy for heart failure (HF): a systematic review and meta-analysis of individual participant data (IPD) and aggregate dataRelationship between hazard ratios (HR) for all-cause mortality and the ratio of change in BNP/NT-proBNP from baseline between the BNP-guided therapy group and symptom-guided therapy group. Filled circles represent the ratio of the change calculated using aggregate data, and open circles represent the ratio of the change calculated using IPD; the change in the position on the x-axis shows the differences between the two analyses methods, while the position on the y-axis remains the sameBack to article page