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Table 3 Descriptive characteristics of eligible RCTs

From: Dietary intakes of flavan-3-ols and cardiovascular health: a field synopsis using evidence mapping of randomized trials and prospective cohort studies

  Total N (%) RCT parallel N (%) RCT crossover N (%)
N publications 223 (100.00) 139 (62.33) 84 (37.67)
Blinding
 Double-blind 124 (55.61) 87 (62.59) 37 (44.05)
 Single-blind 40 (17.94) 19 (13.67) 21 (25.00)
 Not blinded 25 (11.21) 14 (10.07) 11 (13.10)
 Not reported 34 (15.25) 19 (13.67) 15 (17.86)
Mean age
 < 50 years 98 (43.95) 57 (41.01) 41 (48.81)
 ≥ 50 years 125 (56.05) 82 (58.99) 43 (51.19)
Baseline health
 Healthy 65 (29.15) 29 (20.86) 36 (42.86)
 At risk for CVD 127 (56.95) 91 (65.47) 36 (42.86)
 Existing CVD 11 (4.93) 5 (3.60) 6 (7.14)
 Mixed 11 (4.93) 6 (4.32) 5 (5.95)
 Other 9 (4.04) 8 (5.76) 1 (1.19)
Study region
 Africa 2 (0.90) 0 (0.00) 2 (2.38)
 Asia 29 (13.00) 28 (20.14) 1 (1.19)
 Australia 12 (5.38) 6 (4.32) 6 (7.14)
 Eastern Europe 5 (2.24) 5 (3.60) 0 (0.00)
 Western Europe 86 (38.57) 38 (27.34) 48 (57.14)
 Middle East 24 (10.76) 23 (16.55) 1 (1.19)
 North America 59 (26.46) 34 (24.46) 25 (29.76)
 South America 5 (2.24) 4 (2.88) 1 (1.19)
 Mixed 1 (0.45) 1 (0.72) 0 (0.00)
Intervention
 Apple 4 (1.79) 1 (0.72) 3 (3.57)
 Berries 36 (16.14) 24 (17.27) 12 (14.29)
 Black tea 16 (7.17) 9 (6.47) 7 (8.33)
 Chocolate 52 (23.21) 27 (19.42) 25 (29.76)
 Cinnamon 18 (8.07) 17 (12.23) 1 (1.19)
 monomers 9 (4.04) 6 (4.32) 3 (3.57)
 polymers 1 (0.45) 1 (0.72) 0 (0.00)
 Grape 7 (3.14) 4 (2.88) 3 (3.57)
 Grape seed 13 (5.83) 9 (6.47) 4 (4.57)
 Green tea 31 (13.90) 26 (18.71) 5 (5.95)
 Mixed/other 3 (1.35) 3 (2.16) 0 (0.00)
 Tea 8 (3.59) 4 (2.88) 4 (4.76)
 Wine 25 (11.21) 8 (5.76) 17 (20.24)
  1. CVD cardiovascular disease, N number, RCT randomized controlled trial