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Table 1 Objective-specific interventions and comparators

From: Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol

Objectives

Intervention

Comparator

To assess the efficacy of taxanes in comparison to anthracyclines as NACT

Taxanes

Anthracyclines

Taxanes with anthracyclines

To assess the efficacy of targeted therapy along with NACT

Targeted therapy with anthracyclines

Anthracyclines

Targeted therapy with taxanes

Taxanes

Targeted therapy with anthracyclines and taxanes

Anthracyclines and taxanes

To assess the efficacy of trastuzumab along with NACT

Trastuzumab with anthracyclines

Anthracyclines

Trastuzumab with taxanes

Taxanes

Trastuzumab with anthracyclines and taxanes

Anthracyclines and taxanes

To assess the efficacy of Bevacizumab along with NACT

Bevacizumab with anthracyclines

Anthracyclines

Bevacizumab with taxanes

Taxanes

Bevacizumab with anthracyclines and taxanes

Anthracyclines and taxanes

Network Meta-analysis

All possible and feasible pairs of regimen comparison

  1. NACT- Neoadjuvant Chemotherapy