Table 5 Draft analysis plan, analytic method, questions to guide analysis and anticipated review outputs

 1: To identify and assess the documented barriers and supports to HPV and other vaccinations in Canadian and global Indigenous peoples

Thematic synthesis

• What are the documented barriers and supports described in eligible studies?

• What is the quality of the eligible literature? (QATSDD tool)

• What, if any, themes arise in the literature describing barriers and supports to vaccine or HPV vaccine in Canadian and global Indigenous peoples?

• To describe articles that report barriers and/or supports to HPV and other vaccines

• To establish the quality of included articles (item and total study scores)

• To analyze and (where possible) group barriers and facilitators meaningfully across studies

• To analyze any themes among barriers and supports to vaccine or HPV vaccine that are specific to Canadian Indigenous populations

• To statistically analyze measured barriers and supports across studies (should they be deemed appropriate for meta-analysis)

Quantitative Analysis

• What, if any, barriers and supports to vaccine or HPV vaccine in Canadian and global Indigenous peoples are statistically significant?

 2: To identify and assess the documented effective interventions to increase acceptability, uptake or reduce hesitancy of vaccination, and HPV vaccination, in Canadian and global Indigenous peoples

Descriptive statistics,

narrative summary

• What interventions are documented to increase vaccine or HPV vaccine acceptability and uptake and reduce hesitancy in Canadian and global Indigenous populations?

• What is the quality of the eligible literature? (QATSDD tool)

• What, is the nature of vaccine or HPV acceptability, hesitancy and uptake in Canadian and global Indigenous peoples?

• To describe articles that report effective strategies for increasing vaccine or HPV vaccine acceptability, uptake or reducing hesitancy in Canadian and global Indigenous peoples

• To establish the quality of included articles (item and total study scores)

• To describe quantitatively and qualitatively (thematic synthesis) the nature and characteristics of interventions to increase vaccine or HPV vaccine acceptability and uptake or reducing hesitancy in Canadian and global Indigenous peoples

• To synthesize evidence of knowledge, beliefs, and attitudes of Canadian and global Indigenous peoples arising in the eligible literature

Descriptive Analysis

• What are the features (e.g. intervention category, definition, intensity level) and CFIR domain/subdomain assessment of each reported intervention?

• To describe and systematically assess effective interventions and report findings using the CFIR framework domains/subdomains.

 3: To identify and assess documented barriers and supports to vaccination, and HPV vaccination, in youth (< 18 years) within Canadian and global Indigenous peoples.

Thematic synthesis

• What are the documented barriers and supports described in eligible studies for vaccine and HPV vaccine in youth (< 18 years) within Canadian and global Indigenous peoples?

• What is the quality of the eligible literature? (QATSDD tool)

• What, if any, themes arise in the barriers and supports to vaccine or HPV vaccine in youth (< 18 years) in Canadian and global Indigenous peoples?

• To describe articles that report barriers and/or supports to HPV and other vaccines in Canadian and global Indigenous youth (< 18 years)

• To establish the quality of included articles

• To analyze (and where possible) group barriers and facilitators meaningfully across studies

• To analyze any themes among barriers and supports to vaccine or HPV vaccine that are specific to youth (< 18 years) in Canadian Indigenous populations

• Cross-study qualitative synthesis of themes describing barriers and supports

Quantitative Analysis

• What, if any, measured barriers and supports to vaccine or HPV vaccine in youth (< 18 years) in Canadian and global Indigenous peoples are statistically significant?

• To statistically analyze measured barriers and supports across studies (descriptive statistics; based on recent systematic reviews it is unlikely that a meta-analysis will be possible)

 4: To identify and assess documented interventions to increase acceptability and uptake and reduce hesitancy of vaccination and HPV vaccination in youth (< 18 years) within Canadian and global Indigenous peoples.

Descriptive statistics, thematic summary

• What interventions are documented to increase vaccine or HPV vaccine acceptability, uptake and reduce hesitancy in Canadian and global Indigenous youth (< 18 years)?

• What is the quality of the eligible literature?

• What, if any, themes arise in the descriptions of interventions for vaccine or HPV acceptability/hesitancy and uptake in Canadian and global Indigenous youth (< 18 years)?

• To describe articles that report effective strategies for increasing vaccine or HPV vaccine acceptability, uptake or reducing hesitancy in Canadian and global Indigenous peoples

• To establish the quality of included articles

• To describe quantitatively (descriptive statistics) and qualitatively (thematic synthesis) the nature and characteristics of interventions to increase vaccine or HPV vaccine acceptability, uptake or reduce hesitancy in Canadian and global Indigenous youth (< 18 years) (based on recent systematic reviews it is unlikely that a meta-analysis will be possible)

• To synthesize Canadian and global Indigenous youth (< 18 years) knowledge, beliefs and attitudes arising in the eligible literature

• Cross-study qualitative synthesis of themes describing acceptability, uptake and reduced hesitancy interventions

Descriptive Analysis

• What are the features (e.g., intervention category, definition, intensity level) and CFIR domain/subdomain assessment of each reported intervention to increase acceptability and uptake, and reduce hesitancy of vaccination and HPV vaccination in youth (< 18 years) within Canadian and global Indigenous peoples?

• To describe and systematically assess interventions to increase acceptability and uptake, and reduce hesitancy of vaccination and HPV vaccination in youth (< 18 years) within Canadian and global Indigenous peoples, and report findings using the domains/subdomains of the CFIR framework.