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Table 2 Comparison of meta-analytic methods for estimating overall intervention effect in trials to reduce obesity in children aged 6–12 years

From: A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials

Meta-analytic methods Pooled effect size 95%CI τ 2 BIC
Random-effects meta-analysisa − 0.15 [− 0.23, − 0.08]* 0.029 8.08
Stratified meta-analysis
 Explanatory trialsb − 0.32 [− 0.88, 0.33] 0.209 − 11.97
 Pragmatic trialsb − 0.12 [− 0.19, − 0.06]* 0.018 − 9.74
 Meta-regression methods
 REMR controlling for PRECIS − 0.79 [− 1.26, − 0.29]* 0.020 − 5.33
Mixture REMR controlling for PRECIS − 1.01 [− 1.52, − 0.43]* 0.010 − 10.39
  1. τ2 between-trial variance, BIC Bayesian information criterion, REMR random effects mixture regression, 95%CI 95% confidence interval
  2. *p < 0.05
  3. aUnadjusted model