Table 2 Data extraction form

General information

 Affiliation (e.g., academic, commercial, public)

 Country of corresponding author

 Number of authors

 Journal + impact factor

 Disease area(s) (ICD-Code[s])

 Type of intervention (e.g., drug treatment, surgical procedure)

 Scope of SR-HE (only SR-HE/SR-HE and primary CEA/SR-HE to inform primary CEA)

   If only SR-HE: indicated purpose of systematic review

 Study registered or published protocol available (not stated/stated)

 Consideration of reporting guideline (e.g., PRISMA)

Statement of research question and formulated eligibility criteria

 Research question (not stated/stated)

 Eligibility criteria (PICOS + further [specify])

 Economic study types included

Literature search strategy

 Information sources (databases, reference lists of relevant records, etc.)

 Search terms/filters

 + explanation when economic terms missing (e.g., joint review for clinical and economic effectiveness)

 Search limits (time period, language, publication type, etc.)

Study selection

 Flow of study selection described (yes/no)

 Study selection illustrated in flow chart (yes/no)

 Duplicate study selection (yes/no/unclear) + method (e.g., all independently/quality assurance of sample) + mechanism to resolve disagreement

 Technical support for study selection (e.g., software)

Data extraction

 Data extraction method (e.g., standardized data extraction form)

 Duplicate data extraction (yes/no/unclear) + method (e.g., all independently/quality assurance of sample) + mechanism to resolve disagreement

 Data items extracted

 Technical support for data extraction (e.g., software)

Assessment of methodological study quality

 Assessment of methodological study quality on study level (yes/no/unclear) + assessment tool

 Duplicate quality assessment (yes/no/unclear) + method (e.g., all independently/quality assurance of sample) + mechanism to resolve disagreement

Assessment of generalizability/transferability/applicability

 Assessment of generalizability/transferability/applicability (yes/no/unclear) + assessment tool

 Duplicate generalizability/transferability/applicability assessment (yes/no/unclear) + method (e.g., all independently/quality assurance of sample) + mechanism to resolve disagreement

Presentation of cost data

 Presentation of cost data (as reported/inflated/currency converted)

Method for data synthesis

 Data synthesis

 Further remarks