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Table 2 Summary of statistical results for pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) pathological samples

From: Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis

Test property Summary measure of test accuracya (95% CI) Test for heterogeneity
(χ 2) (df = 24) (I 2) p value
PTB (n = 31; b28,406) AUC = 0.99
 Sensitivity 0.82 (0.81–0.83) 586.21 92.8% < 0.001
 Specificity 0.99 (0.99–0.99) 361.23 91.7% < 0.001
 Positive likelihood ratio (PLR) 42.77 (28.23–64.81) 285.01 89.5% < 0.001
 Negative likelihood ratio (NLR) 0.16 (0.12–0.20) 359.13 91.6% < 0.001
 Diagnostic odds ratio (DOR) 324.26 (189.08–556.09) 242.84 87.6% < 0.001
EPTB (n = 25; b6974) AUC = 0.96
 Sensitivity 0.70 (0.67–0.72) 272.48 91.20% < 0.001
 Specificity 0.99 (0.99–0.99) 105.48 77.20% < 0.001
 Positive likelihood ratio (PLR) 29.82 (17.86–49.78) 75.37 68.20% < 0.001
 Negative likelihood ratio (NLR) 0.33 (0.26–0.42) 186.30 87.10% < 0.001
 Diagnostic odds ratio (DOR) 125.20 (65.76–238.36) 70.73 66.10% < 0.001
  1. χ 2 chi-squared, df degree of freedom, I 2 I-squared, n number of studies, CI confidence interval, AUC area under receiver operating characteristics curve, PTB pulmonary tuberculosis, EPTB extra-pulmonary tuberculosis
  2. aRandom-effects model
  3. bNumber of specimens