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Table 2 Summary of planned data extraction from full-text articles selected for inclusion in the scoping review

From: Sex and gender considerations in transplantation research: protocol for a scoping review

Study characteristics Extracted data
 General information • Authors, country of origin, title, year of publication
 Study design • Systematic review/meta-analysis, interventional (RCT), observational (cohort, case-control, cross sectional/survey)
• For longitudinal studies, the beginning and end year of the study
 Study type • Descriptive and/or analytical
 Population characteristics • Selection criteria (inclusion/exclusion)
• Adult, pediatric
• Waitlisted transplant candidates, transplant recipients and/or donors
 Sample size • Number of participants (overall, by sex/gender)
 Type of organ under study • Stem cells, tissues, and/or solid organs
 Exposure, outcome, and covariates • Exposure: health risk factors/predictors
• The main health outcome under study (e.g., patient/graft survival, pharmacokinetics/pharmacodynamics, health services access, utilization, interaction with the healthcare system, cost)
• Covariates
 ° Sex related covariates: anatomy (reproductive organ, proportion of fat and muscle), biological variables (hormones, genetic profile, gene expression), physiological variables (blood and serologic parameters)
 ° Gender-related covariates: gender roles (housework, child care), gender identity (personality traits), gender relationships (social support), institutionalized gender (education level, profession, personal income), behavioral and cultural variables (smoking, drinking, occupation
 Research theme • Biomedical, clinical, health system/services, population health
Sex and gender consideration
 Appropriate application of definitions • Yes
• No (Sex and gender used interchangeably and erroneously)
 Inclusion in the primary research question/objective/hypothesis • Yes
• No
 Consideration in study design • Are both sexes considered? (y/n)
• Were only men or women included? (y/n)
• Was an explanation for sex/gender exclusion/inclusion provided (e.g., not necessary, not feasible)? (y/n)
 Consideration in analysis • How was sex considered in the analyses?
 ° Descriptive (Table 1)
 ° Primary exposure (effect size)
 ° Confounder (included in multivariable models, restriction (sensitivity and/or subgroup analyses) or effect measure modifier (included in interaction terms followed by stratification of the main effect by sex if the interaction term is statistically significant)
• How was gender considered in the analyses?
 ° Gender was accounted for by considering sex-related associations
 ° Gender story was sought by applying second-level disaggregation by sex
 ° Gender story was sought by using gender-related variables
 ° Gender index/score was created to analyze gender independently of sex
  ▪ Summing up different variables to create a score
  ▪ Regression variables to predict male/female sex
  ▪ Factor analysis to capture underlying gender-based constructs
  ▪ Create a ranking based on the male/female distribution to a single variable
 Consideration in study results reporting • Were analyses by sex and/or gender clearly presented in the results section, tables, and/or figures?
 ° Levels of sex and gender integration:
  ▪ Gender unequal
  ▪ Gender blind
  ▪ Gender sensitive
  ▪ Gender specific
  ▪ Gender transformative
 Consideration in the discussion, conclusion, and/or recommendations • Statements, limitations pertinent to sex and gender research