Method label | Package used in R | Contrast-level or arm-level input data | Frequentist or Bayesian framework | Likelihood and link functions | Heterogeneity | Prior distributions | ||
---|---|---|---|---|---|---|---|---|
Treatment-specific fixed effects | Mean effect of treatment k relative to baseline | Heterogeneity or random effects parameter | ||||||
Contrast-synthesis model 1 | gemtc (version 0.8.1) | Arm-level | Bayesian | Binomial likelihood and logit link | Homogeneous/common | N/A | δ k  ~ N(0, (15*5)2)a | τ bk  ~ U(0,10)b |
Contrast-synthesis model 2 | gemtc (version 0.8.1) | Arm-level | Bayesian | Binomial likelihood and logit link | Homogeneous/common | N/A | δ k  ~ N(0, (15*5)2)a | Informativec |
Contrast-synthesis model 3 | netmeta (version 0.9-2) | Contrast-level | Frequentist | N/A | Homogeneous/common | N/A | N/A | N/A |
Arm-synthesis model 1d | pcnetmeta (version 2.4) | Arm-level | Bayesian | Binomial likelihood and probit link | Homogeneous/common | μ k  ~ N(0, 1000) | N/A | σ k  ~ U(0,10) |
Arm-synthesis model 2e | pcnetmeta (version 2.4) | Arm-level | Bayesian | Binomial likelihood and probit link | Heterogeneous | μ k ~ N(0, 1000) | N/A | σ k ~ U(0,10) |