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Table 2 NMA results including certainty assessments

From: Approaches to interpreting and choosing the best treatments in network meta-analyses

Comparison

Number of trials with direct comparisons

Direct estimate (95% CI)

Indirect estimate (95% CrI)

NMA estimate (95% CrI) (higher of direct or indirect confidence)

Light starch vs saline

4

1.07 (0.89, 1.29) M1

0.59 (0.25, 1.35) VL1,2,3

1.04 (0.87, 1.25) M

Heavy starch vs saline

3

0.64 (0.30, 1.37) M1

1.13 (0.71, 1.80) VL1,2

0.95 (0.64, 1.41) M

Albumin vs saline

2

0.81 (0.64, 1.03) M1

0.96 (0.14, 6.31) VL2,4

0.82 (0.65, 1.04) M

Balanced crystalloid vs saline

0

0.78 (0.58, 1.05) L1,2

0.78 (0.58, 1.05) L

Gelatin vs saline

0

1.04 (0.46, 2.32) VL1,2

1.04 (0.46, 2.32) VL

Heavy starch vs light starch

0

0.91 (0.63, 1.33) L1,2

0.91 (0.63, 1.33) L

Albumin vs light starch

0

0.79 (0.59, 1.06) L1,2

0.79 (0.59, 1.06) L

Balanced crystalloid vs light starch

2

0.80 (0.61, 1.04) M3

0.44 (0.19, 0.97) M2

0.75 (0.58, 0.97) M

Gelatin vs light starch

0

1.00 (0.44, 2.21) VL1,2

1.00 (0.44, 2.21) VL

Albumin vs heavy starch

2

1.40 (0.35, 5.56) L4

0.83 (0.52, 1.33) L1,2

0.87 (0.55, 1.36) L

Balanced crystalloid vs heavy starch

1

0.74 (0.52, 1.05) M1

1.35 (0.63, 2.92) VL2,4

0.82 (0.60, 1.13) M

Gelatin vs heavy starch

1

1.09 (0.55, 2.19) L4

1.10 (0.54, 2.21) L

Balanced crystalloid vs albumin

0

0.95 (0.65, 1.38) VL1,2

0.95 (0.65, 1.38) VL

Gelatin vs albumin

0

1.26 (0.55, 2.90) VL2,4

1.26 (0.55, 2.90) VL

Gelatin vs balanced crystalloid

0

1.34 (0.61, 2.89) VL2,4

1.34 (0.61, 2.89) VL

  1. “From Annals of Internal Medicine, Rochwerg B et al, Fluid Resuscitation in Sepsis: A systematic review and network meta-analysis, 161, 5, 347-55.”
  2. CI confidence interval, CrI credible interval; QoE: H high, M moderate, L low, VL very low
  3. 1—rated down for imprecision, 2—rated down for indirectness, 3—rated down for inconsistency (I 2 = 80%, p = 0.03 for heterogeneity), 4—rated down 2 levels for imprecision