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Table 1 Summary of the PICOS elements included in the systematic review

From: Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review

 

Inclusion criteria

Exclusion criteria

Population/patients

Human subjects

Animals

18 years or older

Children

Patients with diagnosed primary hypothyroidism or subclinical hypothyroidism

Pregnant women/patients with secondary or tertiary hypothyroidism/hyperthyroid patients/patients previously treated for thyroid cancer

Receiving levothyroxine treatment

Other forms of hormone replacement therapy/combination therapy

Intervention

Interventions of any type, intensity and frequency, with length greater than 6 weeks used to investigate effect of clinical, behavioural or pharmcogenomic factors on levothyroxine therapy

N/A

Comparators/control

A control or comparative group is necessary. This can be placebo/no treatment/standard therapy/usual care/alternative treatment

No control/comparative group

Outcome

Primary outcome; quantitative effect of clinical/behavioural/pharmacogenomic factors on TSH levels

Secondary outcome (s); quantitative effect of clinical/behavioural/

Pharmacogenomics factors on T4 and T3 levels/any short term effects/mortality/morbidity/quality of life/treatment complications/adverse effects/rate of relapse/physical functioning/social functioning

Reviews only focused on the quantitative effect of clinical/behavioural/

Pharmacogenomics factors on T4 and T3 levels

Study design

RCTs, case-control studies, cohort studies, observational studies, cross sectional studies, longitudinal studies, case studies

N/A