# | First author | Year | Pilot | Power calc. | ITT sample | PP sample | PP sample > median (62.5) | Attrition rate % | Original ITT analysis | ‘Main’ outcome identified | Nature of ‘main’ outcome | End-point |
---|---|---|---|---|---|---|---|---|---|---|---|---|
A42 | Aabel | 2001 | N | N | 51 | 51 | N | 0.0 | N | Daily symptom score (VAS) | Continuous | 10 days |
A43 | Aabel | 2000 | N | Y | 70 | 66 | Y | 5.7 | N | Daily symptom score | Continuous | 32 days |
A44 | Aabel | 2000 | N | Y | 80 | 73 | Y | 8.8 | N | Daily symptom score (VAS) | Continuous | 10 days |
A47 | Baker | 2003 | N | Y | ? | 44 | N | ? | N | Revised Test Anxiety (RTA) scale | Continuous | 4 days |
A48 | bBalzarini | 2000 | N | N | 66 | 61 | N | 7.6 | N | Index of Total Severity during Recovery (re: skin colour, temp, oedema, pigmentation) | Continuous | 7–8 weeks |
A49 | bBeer | 1999 | N | N | 40 | 40 | N | 0.0 | Y | Time between to regular uterine contractions | Continuous | 7 h or induction of labour |
A50 | Belon | 2006 | N | N | 43 | 43 | N | 0.0 | N | Reversal in expression of antinuclear antibody titre | Dichotomous | 1 month |
A51 | Belon | 2007 | Y | N | 39 | 25 | N | 35.9 | N | Blood arsenic concentration | Continuous | 2 months |
A52 | bBergmann (a) | 2000 | N | Y | ? | 37 | N | ? | N | Cycle normalisation | Dichotomous | 3 months or 3 cycles |
A52 | bBergmann (b) | 2000 | N | Y | ? | 30 | N | ? | Y | Cycle normalisation | Dichotomous | 3 months or 3 cycles |
A53 | Bernstein | 2006 | N | N | 200 | 171 | Y | 14.5 | N | Psoriasis Area Severity Index | Continuous | 12 weeks |
A55 | Berrebi | 2001 | N | N | 71 | 71 | Y | 0.0 | N | Mammary pain (VAS) | Continuous | 4 days |
A56 | Bignamini | 1987 | N | N | 34 | 32 | N | 5.9 | N | (Systolic) Blood pressure | Continuous | 4 weeks |
A59 | bCialdella | 2001 | N | Y | 96 | 61 | N | 36.5 | Y | “Success rate” for clinical global impression | Dichotomous | 30 days |
A60 | Clark | 2000 | Y | N | 18 | 14 | N | 22.2 | N | Daily pain (100 mm VAS) | Continuous | 14 days |
A272 | Colau | 2012 | N | Y | 108 | 101 | Y | 6.5 | Y | Hot flash score | Continuous | 12 weeks |
A61 | Cornu | 2010 | Y | Y | 92 | 92 | Y | 0.0 | Y | Cumulated blood loss at drain removal | Continuous | Up to 7 d |
A62 | bDiefenbach | 1997 | N | N | 258 | 209 | Y | 19.0 | Y | Treatment success (‘very good’ + ‘good’ results) – physician-assessed | Dichotomous | Up to 3 weeks |
A63 | bErnst | 1990 | N | N | 122 a | 122 a | N | 0.0 | N | Venous filling time | Continuous | 24 days |
A64 | bFerley | 1989 | N | N | 478 | 462 | Y | 3.3 | N | Proportion of patients recovered (from 5 cardinal symptoms and from temp > 37.5) | Dichotomous | By 48 h |
A67 | Frass | 2005 | N | N | 55 | 50 | N | 9.1 | N | Total volume of tracheal secretions per day | Continuous | 2 days |
A68 | bFreitas | 1995 | N | N | 86 | 69 | Y | 19.8 | N | Score of intensity, frequency and duration of symptoms | Continuous | 6 months |
A69 | Friese | 2007 | N | N | 144 | 68 | Y | 52.8 | Y | Sinusitis symptoms score | Continuous | 21 days |
A70 | bFriese | 1997 | N | Y | 97 | 82 | Y | 15.5 | N | Frequency of non-adenoidectomy (imputed) | Dichotomous | 3 months |
A74 | Gerhard (a) | 1998 | N | Y | 38 | 28 | N | 26.3 | N | Frequency of pregnancy | Dichotomous | 3 months |
A74 | Gerhard (b) | 1998 | N | Y | 27 | 21 | N | 22.2 | N | Frequency of pregnancy | Dichotomous | 3 months |
A74 | Gerhard (c) | 1998 | N | Y | 31 | 17 | N | 45.2 | N | Frequency of pregnancy | Dichotomous | 3 months |
A75 | GRECHO | 1989 | N | Y | 300 | 300 | Y | 0.0 | N | Number of hours from operation until first stool | Continuous | Up to c.100 h |
A274 | Harrison | 2013 | Y | N | 34 | 28 | N | 17.6 | N | Sleep onset latency | Continuous | 28 days |
A76 | Hart | 1997 | N | N | 93 | 73 | Y | 21.5 | N | Frequency of improved pain score (VAS) | Dichotomous | Duration of 5 days |
A78 | Hitzenberger | 2005 | N | Y | ? | ? | - | ? | N | Blood pressure | Continuous | 6 weeks |
A79 | bHofmeyr | 1990 | Y | N | 162 | 161 | Y | 0.6 | N | Daily questionnaire responses: those without moderate/severe perineal pain | Dichotomous | 4 days |
A80 | Jacobs | 2006 | N | N | 292 | 265 | Y | 9.2 | Y | Duration of diarrhoea | Continuous | Up to 7 days |
A81 | Jacobs | 2007 | Y | N | 60 | 58 | N | 1.7 | N | No. of days until no pain or fever for at least two consecutive days | Continuous | Up to 1 weeks |
A83 | bKaziro | 1984 | N | N | 77 | 77 | Y | 0.0 | N | Pain score (VAS): Numbers without moderate/severe pain (imputed) | Dichotomous | 8 days |
A84 | Khuda-Bukhsh | 2005 | Y | N | 55 | 55 | N | 0.0 | N | Urine arsenic concentration (imputed) | Continuous | 11 days |
A85 | Khuda-Bukhsh | 2011 | Y | N | 28 | 14 | N | 50.0 | N | Urine arsenic concentration | Continuous | 2 months |
A86 | Kim | 2005 | Y | Y | 40 | 34 | N | 15.0 | Y | Rhinoconjunctivitis Quality-of-Life Questionnaire (RQLQ total symptoms) | Continuous | 4 weeks |
A88 | Kolia-Adam | 2008 | N | N | 30 | 30 | N | 0.0 | N | Hours of sleep per night | Continuous | 8 weeks |
A89 | Kotlus | 2010 | N | N | 60 | 57 | N | 5.0 | N | Area of ecchymosis | Continuous | 7 days |
A91 | Labrecque | 1992 | N | Y | 174 | 162 | Y | 6.9 | N | Proportion of pts with healed warts (physician assessment) | Dichotomous | 18 weeks |
A92 | bLeaman | 1989 | N | N | 34 | 34 | N | 0.0 | N | Pain (0-10 VAS) - area-under-the-curve | Continuous | 6 h |
A93 | Lewith | 2002 | N | N | 242 | 202 | Y | 16.5 | Y | Asthma VAS (imputed) | Continuous | 16 weeks |
A94 | Lipman | 1999 | N | N | 101 | 90 | Y | 10.9 | N | Average snoring score computed from responses to Snore Diary over last 5 nights of 10 | Continuous | Duration of 10 days |
A293 | Malapane | 2014 | Y | N | 30 | 30 | N | 0.0 | N | Tonsillitis pain score (Wong-Baker FACES) | Continuous | 6 days |
A95 | McCutcheon | 1996 | N | N | 77 | 58 | N | 24.7 | N | State Anxiety score | Continuous | Duration of 15 days |
A275 | Naidoo | 2013 | Y | N | 30 | 30 | N | 0.0 | N | Wheal diameter | Continuous | 4 weeks |
A100 | Oberbaum | 2001 | N | N | 32 | 30 | N | 6.3 | Y | Area-under-the-curve score for stomatitis symptoms (severity and duration) (imputed) | Continuous | 14 days minimum |
A101 | bOberbaum | 2005 | Y | N | 45 | 40 | N | 11.1 | Y | Venous haemoglobin | Continuous | 72 h postpartum |
A103 | Padilha | 2011 | N | N | 131 | 120 | Y | 8.4 | Y | Proportion of workers with Pb decrease of at least 25% (imputed) | Dichotomous | 30 days |
A104 | bPapp | 1998 | N | N | 372 | 334 | Y | 10.2 | N | Proportion of patients with physician-assessed recovery in health (i.e. ‘no symptoms’) | Dichotomous | By 48 h |
A105 | Paris | 2008 | N | Y | 131 | 105 | Y | 19.8 | Y | Proportion patients with cumulated consumption of morphine < 10 mg/day (imputed) | Dichotomous | 24 h post-op |
A108 | bRahlfs | 1976 | Y | Y | ? | 63 | Y | ? | N | Improvement of irritable bowel syndrome (scale 1 + 2) | Dichotomous | 14 days |
A109 | bRahlfs | 1978 | Y | N | 119 | 85 | Y | 28.6 | N | Improvement of irritable bowel syndrome (scale 3 + 4) | Dichotomous | 15 days |
A277 | Razlog | 2012 | Y | N | 20 | 18 | N | 10.0 | N | Conner’s PSQ (‘Impulsivity and/or hyperactivity’ category) | Continuous | 3 weeks |
A111 | bReilly | 1986 | N | Y | 158 | 109 | Y | 31.6 | N | Propn. with improvement in daily overall VAS score (imputed) | Dichotomous | 5 weeks |
A112 | bReilly | 1994 | N | Y | 28 | 24 | N | 14.3 | Y | Propn. with improvement in daily overall VAS score | Dichotomous | 4 weeks |
A113 | Robertson | 2007 | N | Y | 190 | 111 | Y | 41.6 | N | Tonsillectomy pain (VAS) score | Continuous | 14 days |
A116 | Schmidt | 2002 | N | Y | 208 | 194 | Y | 6.7 | Y | Reduction of body weight | Continuous | 3 days |
A117 | Seeley | 2006 | N | N | 29 | 26 | N | 10.3 | N | Area of ecchymosis | Continuous | 10 days |
A278 | Sencer | 2012 | N | Y | 195 | 106 | Y | 45.6 | N | Sum of Walsh scores for mucositis | Continuous | Up to 20 days post-transplant |
A120 | Singer | 2010 | N | Y | 80 | 79 | Y | 1.3 | Y | Area-under-the-curve pain score | Continuous | 14 days |
A122 | Stevinson | 2003 | Y | N | 64 | 62 | N | 3.1 | Y | Pain (Short Form McGill Pain Questionnaire | Continuous | 14 days |
A123 | bTaylor | 2000 | N | Y | 51 | 50 | N | 2.0 | Y | Daily overall VAS score (imputed) | Continuous | 3–4 weeks |
A125 | Tveiten | 1991 | N | N | 44 | 36 | N | 18.2 | N | Muscle soreness (VAS) (imputed) | Continuous | 3 days |
A126 | bTveiten | 1998 | N | N | ? | 46 | N | ? | N | Muscle soreness (VAS) | Continuous | 3 days |
A128 | bVickers | 1998 | N | Y | ? | 400 | Y | ? | Y | Muscle soreness (VAS) | Continuous | 2 days |
A130 | Weiser | 1994 | N | Y | 173 | 155 | Y | 10.4 | N | Sinusitis score | Continuous | 5 months or on relapse |
A131 | bWiesenauer | 1985 | N | N | 106 | 74 | Y | 30.2 | N | Symptom relief (nasal): ‘Symptom-free’ + ‘Obvious relief’ | Dichotomous | 4 weeks |
A132 | Wiesenauer | 1989 | N | N | 221 | 152 | Y | 31.2 | N | Sinusitis score | Continuous | 3–4 weeks |
A133 | bWiesenauer | 1990 | N | N | 243 | 171 | Y | 29.6 | N | Symptom relief (nasal): ‘Symptom-free’ + ‘Obvious relief’ | Dichotomous | Approx 5 weeks |
A134 | Wiesenauer | 1991 | N | N | 176 | 106 | Y | 39.8 | N | Treatment success | Dichotomous | 12 weeks |
A135 | bWiesenauer | 1995 | N | N | 132 | 120 | Y | 9.1 | N | Symptom relief (nasal): ‘Symptom-free’ + ‘Obvious relief’ | Dichotomous | 4 weeks |
A136 | Wolf | 2003 | Y | N | 60 | 59 | N | 1.7 | N | Haematoma area | Continuous | 2 weeks |
A137 | Zabolotnyi | 2007 | N | Y | 113 | 113 | Y | 5.3 | Y | Sinusitis severity score cf. Day 0 (imputed) | Continuous | 7 days |