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Table 5 Subgroup analysis of between-session MEP amplitude reliability

From: The number of stimuli required to reliably assess corticomotor excitability and primary motor cortical representations using transcranial magnetic stimulation (TMS): a systematic review and meta-analysis

  Pooled ICC (95% CI)
Subgroup N 3 stimuli 4 stimuli 5 stimuli 10 stimuli 15 stimuli
Healthy only 5 NA 0.65 (0.15 to 0.88) 0.79 (0.62 to 0.89) 0.89 (0.76 to 0.95) 0.91 (0.70 to 0.98)
CVA only 1 NA 0.28 (−0.29 to 0.71) NA 0.30 (−0.33 to 0.75) NA
Age <65 years 5 NA 0.48 (0.04 to 0.76) 0.82 (0.64 to 0.91) 0.83 (0.56 to 0.94) 0.91 (0.70 to 0.98)
Age >65 years 1 NA NA 0.65 (0.03 to 0.91) NA NA
Upper limb onlya 3 NA NA 0.82 (0.64 to 0.91) 0.94 (0.76 to 0.99) 0.95 (0.89 to 0.98)
Lower limb onlyb 2 NA 0.48 (0.04 to 0.76) NA 0.63 (−0.10 to 0.92) NA
Submental group only 1 NA NA 0.66 (0.05 to 0.91) 0.72 (0.16 to 0.95) 0.69 (0.11 to 0.92)
<72 h between sessions 4 NA NA 0.79 (0.62 to 0.89) 0.90 (0.74 to 0.97) 0.91 (0.70 to 0.98)
>72 h between sessions 2 NA 0.48 (0.04 to 0.76) NA 0.63 (−0.10 to 0.92) NA
  1. ICC intraclass correlation coefficient, CI confidence interval, N number of participant cohorts, CVA participants with 6 months post-cerebrovascular accident, NA not available
  2. aAlso, analysis of resting conditions only
  3. bAlso, analysis of active conditions only