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Table 1 Description of neuroimaging features of cerebral small vessel disease on MRI

From: What is the relationship between type 2 diabetes mellitus status and the neuroradiological correlates of cerebral small vessel disease in adults? Protocol for a systematic review

  International consensus definition [2] Common rating scales/definitions Examples of features counted as “present” in review
White matter hyperintensities (WMH) Signal abnormality of variable size in the white matter with hyperintensity on T2-weighted images without cavitation • Age-related white matter changes (ARWMC) score
• Fazekas score
• Scheltens score
• Quantitative volumetric measurements
• ARWMC score of 5 or greater (moderate–severe)
• Fazekas periventricular = 3 and/or deep ≥2
• WMH volume ≥7.7 mL [3]
Lacunar infarcts Round/ovoid subcortical fluid-filled cavity 3–15 mm in diameter in the territory of one perforating arteriole   ≥1 lacune
Cerebral microbleeds (CMB) Small (≤10 mm) areas of signal void with associated blooming on T2*-MRI or other sequences sensitive to susceptibility effects • Brain observer microbleed score (BOMBS)
• Microbleed anatomical rating scale (MARS)
≥1 microbleed
Enlarged perivascular spaces (PVS) Fluid-filled spaces following the typical course of a vessel through grey or white matter, isointense to CSF on all sequences. Linear when images parallel to the vessel and round or ovoid when perpendicular. In constrast with lacunes, no T2-hyperintense rim on T2/FLAIR unless they traverse WMH • Edinburgh score