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Table 2 Sensitivity analysis of the risk of serious adverse events associated with hyaluronic acid for osteoarthritis of the knee

From: Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews

  Relative risk (RR) (95 % confidence interval (CI)) RR (95 % CI) excluding outlier study by Jubb et al. [64]
Pooled SAE results in our review 1.39 (0.78–2.47)
Original pooled SAE results in Rutjes et al. [8]   
- All studies 1.41 (1.02–1.97)
- Sample restricted to “large, blinded trials” 1.55 (1.07–2.24)
Our approximated pooled SAE results (data imputed for studies in Rutjes et al. [8] with proprietary data)   
- All studies 1.42 (1.01–1.99) 1.26 (0.83–1.90)
- Sample restricted to “large, blinded trials” 1.54 (1.05–2.28) 1.37 (0.83–2.26)
Approximated pooled SAE results including omitted SAEs (two cases of myocardial infarction [54, 75], four cases of severe knee swelling [54], one case of cerebral hemorrhage [26], and one case of breast cancer [75])   
- All studies 1.37 (0.98–1.91) 1.21 (0.82–1.80)
- Sample restricted to “large, blinded trials” 1.50 (1.03–2.19) 1.32 (0.82–2.13)
Approximated pooled SAE results excluding four cancer cases [73]   
- All studies 1.36 (0.97–1.89) 1.20 (0.81–1.77)
- Sample restricted to “large, blinded trials” 1.48 (1.02–2.16) 1.30 (0.81–2.09)
Approximated pooled SAE results including omitted non-cancer SAEs (two cases of myocardial infarction [54, 75], four cases of severe knee swelling [54], one case of cerebral hemorrhage [26]) and excluding four cancer cases [73]   
- All studies 1.37 (0.98–1.91) 1.21 (0.81–1.80)
- Sample restricted to “large, blinded trials” 1.50 (1.03–2.18) 1.32 (0.82–2.12)
  1. This table compares the SAE results in our review, the review by Rutjes et al. [8], our approximation of their results, and the sensitivity of those approximated results to the inclusions and exclusion of individual AEs and the outlier study by Jubb et al. [64]