Table 3 Case study B: comparison of PICO (population, intervention, comparator, outcome) criteria between the existing systematic reviews (Galvao et al. [14], Jefferson et al. [15], Fell et al. [13], and McMillan et al. [16]) and our own new review
| Â | Galvao et al. [14] | Jefferson et al. [15] | Fell et al. [13] | McMillan et al. [16] | Own new review |
|---|---|---|---|---|---|
Population | Pregnant women and their infants | Pregnant women and their newborns | Pregnant women and their infants | Pregnant women, their fetuses and infants up to 6Â months of age | Pregnant women and their infants |
Intervention | Vaccination against influenza | Live attenuated or inactivated vaccines | Vaccination against influenza | Inactivated influenza vaccination | Vaccination against seasonal influenza |
Comparator | Placebo or other vaccines or no vaccination | Placebo or no vaccination | No vaccination | No vaccination | Placebo or no vaccination |
Outcome | Influenza-related outcomes in mother or infant | Symptomatic influenza and influenza-like illness; maternal and pregnancy outcomes; neonatal outcomes: congenital malformations, neonatal death | Preterm birth, early fetal death, late fetal death | Influenza, influenza-like illness, for pregnant women: adverse events and serious adverse events; for the fetus: spontaneous abortion, fetal death, premature birth, low birth weight, small for gestational age, congenital malformation | Laboratory-confirmed influenza in mother and/or infant; any severe adverse event in mother or infant |