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Table 1 Study quality/risk of bias for individual included studies

From: A systematic review of St. John’s wort for major depressive disorder

Study ID Recruitment method (random sequence generation) Allocation concealment Blinding of participants and personnel Blinding of outcome assessment Incomplete outcome data Selective reporting of outcome data Other: all receive TAU, only treatment group receives SJW (no placebo for controls) Other: appropriate washout period or exclusion of individuals taking personal supplements Other: baseline assessment, appropriate statistical analysis, COI) USPSTF quality rating (good, fair, poor)
Behnke, 2002 [17] Unclear risk Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk NA Low risk Poor
Bernhardt, 1993 [16] Unclear risk Unclear risk High risk High risk Unclear risk Unclear risk Low risk NA Unclear risk Poor
Bjerkenstedt, 2005 [18] Unclear risk Unclear risk Low risk Low risk Low risk Unclear risk Low risk NA Low risk Fair
Brenner, 2000 [19] Unclear risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Fava, 2005 [20] Unclear risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Poor
Gastpar, 2005 [21] Low risk Unclear risk Low risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Gastpar, 2006 [22] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
HDTSG, 2002 [23] Low risk Low risk Low risk Low risk Unclear risk Low risk Low risk NA Low risk Fair
Hangsen, 1994 [48] Low risk Low risk Low risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Harrer, 1993 [24] Low risk Unclear risk Low risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Harrer, 1999 [25] Unclear risk Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Kalb, 2001 [26] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Kasper, 2006 [27] Low risk Low risk Low risk Low risk Unclear risk Low risk Low risk NA Low risk Fair
Kasper, 2008 [28] Low risk Low risk Low risk Unclear risk Low risk Low risk Low risk Low risk Low risk Fair
Laakmann, 1998 [29] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Lecrubier, 2002 [30] Unclear risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Lenoir, 1999 [31] Unclear risk Low risk Unclear risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Liu, 2010 [32] High risk Unclear risk High risk Unclear risk Low risk Unclear risk Low risk NA Low risk Poor
Mannel, 2010 [33] Low risk Low risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Montgomery, 2000 [34] Unclear risk Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk NA Unclear risk Poor
Moreno, 2005 [35] Unclear risk Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Pakseresht, 2012 [36] Unclear risk Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Philipp, 1999 [37] Unclear risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Rahman, 2008 [38] Low risk Low risk Low risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Schrader, 1998 [40] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Schrader, 2000 [39] Unclear risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Shelton, 2001 [41] Low risk Low risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Szegedi, 2005 [42] Low risk Low risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
Uebelhack, 2004 [43] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Volz, 2000 [50] Unclear risk Low risk Low risk Low risk Low risk Unclear risk Low risk NA Low risk Good
Vorbach, 1997 [44] Low risk Unclear risk Low risk Unclear risk Unclear risk Unclear risk Low risk NA Low risk Poor
Wheatley, 1997 [45] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Good
Witte. 1995 [49] Unclear risk Low risk Low risk High risk Low risk Unclear risk Low risk NA Low risk Good
Woelk, 2000 [46] Low risk Unclear risk Low risk Unclear risk Low risk Unclear risk Low risk NA Low risk Fair
van Gurp, 2002 [47] Low risk Low risk Low risk Low risk Low risk Unclear risk Low risk NA Low risk Fair
  1. SJW St. John’s wort, ITT intention-to-treat analysis, TAU treatment as usual