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Table 4 The relative risk (95 %) for breast cancer according to the route of administration of estradiol and the type of progestogen used

From: Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis

Study name Type of MHT Progesterone Synthetic progestins
Espie et al. 2007 [16] Oral estradiol NR 0.81 (0.23–2.85)
Transdermal estradiol 0.46 (0.13–1.62) 1.07 (0.50–2.27)
  1. NR not reported in the study