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Table 2 Quantitative measures of severity of pulmonary hypertension
| Collection method | Parameter | Surrogate index for | Type of variable |
|---|---|---|---|
| Direct measurement | Right ventricular systolic pressure (RVSP) | Pulmonary hemodynamics [12, 30] | Continuous |
| Mean pulmonary arterial pressure (mPAP) | Pulmonary hemodynamics [12, 30] | Continuous | |
| Cardiac output, cardiac index | Cardiac function [12, 30] | Continuous (calculated) | |
| Pulmonary vascular resistance (PVR) | Pulmonary hemodynamics | Continuous (calculated) | |
| Post-mortem tissue collection | Morphometric RV hypertrophy (RV/LV+S) | RV remodeling [12, 30] | Continuous |
| Echocardiography | Pulmonary artery acceleration time (PAT) | Pulmonary hemodynamics [12, 30] | Continuous |
| RV free wall thickness | RV remodeling [12, 30] | Continuous | |
| Tricuspid annular plane systolic excursion (TAPSE) | Cardiac function | Continuous | |
| Ratio of deaths/total participants at experimental endpoint | Death | Mortality | Continuous |
| Survival time relative to induction | Survival | Survival | Continuous |
