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Table 2 Quantitative measures of severity of pulmonary hypertension

From: Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol

Collection method Parameter Surrogate index for Type of variable
Direct measurement Right ventricular systolic pressure (RVSP) Pulmonary hemodynamics [12, 30] Continuous
  Mean pulmonary arterial pressure (mPAP) Pulmonary hemodynamics [12, 30] Continuous
  Cardiac output, cardiac index Cardiac function [12, 30] Continuous (calculated)
  Pulmonary vascular resistance (PVR) Pulmonary hemodynamics Continuous (calculated)
Post-mortem tissue collection Morphometric RV hypertrophy (RV/LV+S) RV remodeling [12, 30] Continuous
Echocardiography Pulmonary artery acceleration time (PAT) Pulmonary hemodynamics [12, 30] Continuous
  RV free wall thickness RV remodeling [12, 30] Continuous
  Tricuspid annular plane systolic excursion (TAPSE) Cardiac function Continuous
Ratio of deaths/total participants at experimental endpoint Death Mortality Continuous
Survival time relative to induction Survival Survival Continuous