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Table 4 User patterns of risk of bias implementations in Cochrane and non-Cochrane reviews—evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials

From: Evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials: overview of published comments and analysis of user practice in Cochrane and non-Cochrane reviews

Risk of bias implementation

100 Cochrane reviews (100 %)

100 non-Cochrane reviews (100 %)

P value*

Risk of bias assessment in reviews

   

 Any risk of bias (or quality) assessment

100 (100 %)

80 (80 %)

0.30

  Cochrane risk of bias tool

100 (100 %)

31 of 80 (39 %)

0.0002

  Jadad scale

0 (0 %)

19 of 80 (24 %)

0.0001

  PEDro scale

0 (0 %)

5 of 80 (6 %)

0.019

  Own construct or other scale

0 (0 %)

25 of 80 (31 %)c

0.0001

Descriptive use of risk of bias assessment

   

 Explicit mentions risk of bias in abstract

80 (80 %)

18 of 31d (58 %)

0.42

 Explicit mentions risk of bias in discussion/conclusion

89 (89 %)

25 of 31d (81 %)

0.76

 Explicit mentions risk of bias in both abstract and discussion/conclusion

73 (73 %)

15 of 31d (48 %)

0.31

Sensitivity and subgroup analyses based on risk of bias

   

 Review planned (in methods) to do sensitivity analyses

70 (70 %)

8 of 80 (10 %)

0.0001

 Review performed sensitivity analyses

19 (19 %)

11 of 80 (14 %)

0.55

  Based on overall risk of bias

2 of 19 (11 %)

9 of 11 (82 %)

0.015

  Based on individual risk of bias domains

9 of 19 (47 %)

2 of 11 (18 %)

0.45

  Unclear what analyses were based on

8 of 19 (42 %)

0 of 11 (0 %)

0.077

 Review performed, but did not plan sensitivity analyses

1 of 19 (5 %)

8 of 11 (72 %)

0.0084

 Review performed subgroup analysesa

2 (2 %)

0 of 80 (0 %)

0.50

 Review planned, but did not perform analyses

50 of 70 (71 %)

5 of 8

0.52

  Due to insufficient datab

41 of 50 (82 %)

3 of 5

0.73

  No explanation provided

9 of 50 (18 %)

2 of 5

0.33

GRADE

 Review incorporated GRADE

64 (64 %)

4 of 80 (5 %)

0.0001

  1. *P values were calculated with Fisher’s two-tailed exact test
  2. aAll subgroup analyses were based on “low” versus “high” risk of bias
  3. b“Insufficient data” was due to few trials included in the review or few trials judged as “low risk of bias”
  4. c15 non-Cochrane reviews made their own risk of bias construct/tool, eight incorporated two constructs/tools and the following constructs/tools (/methods) were used 18 times in total: CASP (×2), CEBM, Chalmers, CONSORT (×2), CTAM, Downs and Black criteria (×2), Evidence-based medicine toolkit, GRADE (×2), Methods Guide for Effectiveness and Comparative Effectiveness Reviews, MOOSE (×2), Newcastle Ottawa, QUOROM and STROBE
  5. d31 of 100 non-Cochrane reviews used the Cochrane risk of bias tool for randomized clinical trials (i.e. the tool) and were compared to the 100 Cochrane reviews that used the tool for randomized clinical trials