Table 1 Search strategy for the MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases

MEDLINE

Set

History

Comments

1

(((kidney* or nephro* or renal or home or peritoneal or intermittent or chronic or extracorporeal or ambulatory) adj2 (haemodialys* or hemodialys* or dialys*)) or hemorenodialysis or hemodialyse or CAPD).ti,ab.

Dialysis textword search Terms

2

renal dialysis/ or hemodialysis, home/ or peritoneal dialysis/ or peritoneal dialysis, continuous ambulatory/

Dialysis subject Terms

3

renal insufficiency, chronic/ or kidney failure, chronic/

Chronic kidney disease subject terms

4

(((chronic or "end-stage" or "end stage") adj3 (kidney* or renal or nephro*) adj3 (insufficien* or disease*)) or esrd).ti,ab.

Chronic kidney disease textword terms

5

frasier syndrome/ or ("frasier* syndrome*" or (frasier* adj2 syndrome*)).mp.

Syndrome subject and textword terms

6

renalosteodystrophy/ or ((renal or kidney* or nephro*) adj2 (osteodystroph* or ricket*)).mp.

Chronic kidney disease subject or textword Terms

7

azotemia/ or azotemi*.mp.

Azotemia subject or textword Terms

8

uremia/ or uremi*.mp.

Uremia disease subject or textword Terms

9

or/1-1

Kidney disease terms

10

Calcimimetic Agents/ or (Calcimimetic* or amg073 or cinacalcet or "krn 1493" or krn1493 or mimpara or parareg or regpara or sensipar).mp.

Cinacalcet subject and textword search Terms

11

9 and 10

Base clinical set

12

controlled clinical trial.pt. or controlled clinical trials as topic/ or meta analysis.pt. ormeta analysis as topic/ or multicentre study.pt. or multicenter studies as topic/ or randomized controlled trial.pt. or randomized controlled trials as topic/ or pragmatic clinical trial.pt. or Pragmatic Clinical Trials as Topic/ or ((preference or practical or pragmatic or "real world" or naturalistic) adj5 trial*).ti,ab. or Comparative Effectiveness Research/ or ((comparative adj2 effectiveness) or (CER adj5 (research* or method* or framework* or compari* or statement*))).ti,ab. or ((singl: or doubl: or tripl: or trebl:) and (mask: or blind:)).ti,ab. or ((random: adj5 trial:) or rct or rcts).ti,ab.

Therapy Study design methodologies

13

11 and 12

FINAL Results

EMBASE

Set

History

Comments

1

(((kidney* or nephro* or renal or home or peritoneal or intermittent or chronic or extracorporeal or ambulatory) adj2 (haemodialys* or hemodialys* or dialys*)) or hemorenodialysis or hemodialyse or CAPD).ti,ab.

Dialysis textword search Terms

2

renal replacement therapy/ or continuous ambulatory peritoneal dialysis/ or continuous renal replacement therapy/ or extended daily dialysis/ or hemodialysis/ or home dialysis/ or peritoneal dialysis/

Dialysis subject Terms

3

kidney failure/ or chronic kidney failure/

Chronic kidney disease subject terms

4

(((chronic or "end-stage" or "end stage") adj3 (kidney* or renal or nephro*) adj3 (insufficien* or disease*)) or esrd).ti,ab.

Chronic kidney disease textword terms

5

frasier syndrome/ or ("frasier* syndrome*" or (frasier* adj2 syndrome*)).mp.

Syndrome subject and textword terms

6

renalosteodystrophy/ or ((renal or kidney* or nephro*) adj2 (osteodystroph* or ricket*)).mp. (7537)

Chronic kidney disease subject or textword Terms

7

azotemia/ or azotemi*.mp.

Azotemia subject or textword Terms

8

uremia/ or uremi*.mp.

Uremia disease subject or textword Terms

9

Or/1-8

Kidney disease terms

10

Calcimimetic Agent/ or cinacalcet/ or (Calcimimetic* or amg073 or cinacalcet or "krn 1493" or krn1493 or mimpara or parareg or regpara or sensipar).mp.

Cinacalcet subject and textword search Terms

11

9 and 10

Base clinical set

12

ct.fs. or controlled clinical trial.pt. or controlled clinical trial/ or meta analysis/ or multicenter study/ or randomized controlled trial.pt. or randomized controlled trial/ or double blind procedure/ or single-blind procedure/ or triple blind procedure/ or ((preference or practical or pragmatic or "real world" or naturalistic) adj5 trial*).ti,ab. or comparative effectiveness/ or ((comparative adj2 effectiveness) or (CER adj5 (research* or method* or framework* or compari* or statement*))).ti,ab. or ((random: adj5 trial:) or rct or rcts).ti,ab. or ((singl: or doubl: or tripl: or trebl:) and (mask: or blind:)).ti,ab.

Therapy Study design methodologies

13

11 and 12

FINAL Results

EBM Reviews - Cochrane Central Register of Controlled Trials

Set

History

Comments

1

((kidney* or nephro* or renal or home or peritoneal) adj2 (haemodialys* or hemodialys* or dialys*)).ti,ab. or renal dialysis/ or hemodialysis, home/ or peritoneal dialysis/ or peritoneal dialysis, continuous ambulatory/ or renal insufficiency, chronic/ or kidney failure, chronic/ or (((chronic or "end-stage" or "end stage") adj3 (kidney* or renal or nephro*) adj3 (insufficien* or disease*)) or esrd).ti,ab. or frasier syndrome/ or ("frasier* syndrome*" or (frasier* adj2 syndrome*)).mp. or renal osteodystrophy/ or ((renal or kidney* or nephro*) adj2 (osteodystroph* or ricket*)).mp. or azotemia/ or azotemi*.mp. or uremia/ or uremi*.mp. or (((kidney* or nephro* or renal or home or peritoneal or intermittent or chronic or extracorporeal or ambulatory) adj2 (haemodialys* or hemodialys* or dialys*)) or hemorenodialysis or hemodialyse or CAPD).ti,ab. or kidney failure/ or chronic kidney failure/ or frasier syndrome/ or renal osteodystrophy/ or uremia/ or (((chronic or "end-stage" or "end stage") adj3 (kidney* or renal or nephro*) adj3 (insufficien* or disease*)) or esrd).ti,ab. or kidney failure/ or chronic kidney failure/ or frasier syndrome/ or ("frasier* syndrome*" or (frasier* adj2 syndrome*)).mp. or renal osteodystrophy/ or ((renal or kidney* or nephro*) adj2 (osteodystroph* or ricket*)).mp. or azotemia/ or azotemi*.mp. or uremia/ or uremi*.mp.

Dialysis, chronic kidney diseases Subject or textword search Terms

2

Calcimimetic Agent/ or cinacalcet/ or Calcimimetic Agents/ or (Calcimimetic* or amg073 or cinacalcet or "krn 1493" or krn1493 or mimpara or parareg or regpara or sensipar).mp.

Cinacalcet subject and textword search Terms

3

1 and 2

Base clinical set