|
Yamaguchi et al. [24]
|
Japan
|
Oct 1998–June 2005
|
Cross-sectional
|
n = 64
|
Mean, range = 60.7, 24–85
|
12:52
|
Disease duration (<1 year, <5, <10, >10): n = 19, n = 17, n = 18, n = 10
|
H. pylori: positive (n = 37), negative (n = 27)
|
H. pylori positive
|
|
% reflux esophagitis 27
|
|
% diffuse disease 17
| |
H. pylori negative
|
|
% smoking 30
|
% reflux esophagitis 70
|
|
% alcohol 34
|
|
% corticosteroid use 72
|
|
Hudson et al. [25]
|
Canada
|
Aug 2004–Nov 2009
|
Cross-sectional
|
n = 606
|
Mean, SD = 55, 12
|
79:527
|
% Caucasian: 87.0
|
Smoking status: never (n = 255), past (n = 252; mean pack-years of smoking = 17, SD = 18), current (n = 99; mean pack-years of smoking = 25, SD = 17)
|
Never
|
Current
|
|
Disease duration (mean, SD): 11, 9
|
Mean severity of GI symptoms: 1.61 out of 10
|
Mean severity of GI symptoms: 2.18 out of 10
|
|
% diffuse disease 36.0
|
Mean number of GI symptoms: 3.99 out of 14a
|
Mean number of GI symptoms: 4.91 out of 14a
|
|
% poor appetite 28.6a
|
% poor appetite 47.5a
|
|
% difficulty swallowing 54.1
|
% difficulty swallowing 59.6
|
|
% acid reflux 60.8
|
% acid reflux 68.7
|
|
% nocturnal choking 28.6
|
% nocturnal choking 29.3
|
|
% heartburn 41.6
|
% heartburn 54.5
|
|
% early satiety 38.8
|
% early satiety 51.5
|
|
% abdominal bloating 34.9
|
% abdominal bloating 43.4
|
|
% nausea and vomiting 14.1
|
% nausea and vomiting 23.2
|
|
% chronic constipation 25.5
|
% chronic constipation 32.3
|
|
% chronic diarrhea 23.9
|
% chronic diarrhea 26.3
|
|
% antibiotics for bacterial overgrowth 7.5
|
% antibiotics for bacterial overgrowth 6.1
|
|
% greasy stools 18.8
|
% greasy stools 24.2
|
|
% fecal incontinence 19.2
|
% fecal incontinence 22.2
|
|
% parenteral nutrition 2.4
|
% parenteral nutrition 2.0
|
|
% taking medications for GI symptoms 73.7
|
% taking medications for GI symptoms 59.6
|
|
% taking medications for GI symptoms 67.1
|
|
Radic et al. [26]
|
Croatia
|
Jan 2009–Dec 2010
|
Cross-sectional
|
n = 42
|
Mean, SD = 54.3, 13.6
|
4:38
|
Disease duration (median, range): 6, 1–43 years
|
H. pylori: positive (n = 26), negative (n = 16)
|
H. pylori positive
|
|
% GI problems 85
|
|
% diffuse disease 95.3
|
H. pylori negative
|
|
% GI problems 31
|
