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Table 1 Outcome measures

From: The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol

Outcome

Measurement of variable (units)

Statistical estimates and measurement of association of this outcome

Menstrual regulation

Number of girls achieved regular menses

Rate ratio

Number of cycles per year

Mean difference ± SD

Hirsutism

Ferriman Gallawey score

Mean difference ± SD

Acne scores

Lesion counting or grading

Standardized mean difference ± SD

Dysglycaemia

The rate of occurrence of T2DM, impaired glucose tolerance, and impaired fasting glucose assessed by oral glucose tolerance test and/or fasting blood glucose, and/or HBA1c

Rate ratio

BMI

kg/m2

Mean difference ± SD

Total testosterone level

ng/ml

Mean difference ± SD

Total cholesterol

mg/dl

Mean difference ± SD

LDL

mg/dl

Mean difference ± SD

HDL

mg/dl

Mean difference ± SD

Triglyceride

mg/dl

Mean difference ± SD

Adverse events

Number of girls developed:

OR, rate ratio

1- GI: all GI related adverse events:

 • Nausea

 • Vomiting

 • Diarrhea

 • Constipation

 • Abdominal pain

 • Flatulence

 • Gastritis

 • GI bleeding

2- thrombosis: all vascular events related to thrombus formation such as:

 • Deep venous thrombosis

 • Stroke

 • Myocardial infarction

 • Pulmonary embolism

3- serious: adverse events that are of major morbidity such as:

 • Any bleeding not including GI bleed

 • Lactic acidosis

 • Liver failure

 • Renal failure

 • Vasculitis

 • Electrolyte imbalance

 • Agranulocytosis

 • Photosensitivity

 • Hypertension

 • Pancreatitis

 • Anaphylaxis

 • Chorea

 • Depression

4- minor: adverse events that are of minor morbidity such as:

 • Headache

 • Fatigue

 • Beast tenderness

 • Vaginal bleeding (spotting)

 • Edema

 • Weight gain

 • Metallic taste

 • Muscle cramp

 • Rash

 • Fever

 • Hot flashes

 • Glucose intolerance

 • Infection

  1. OR odds ratio, T2DM type 2 diabetes mellitus, BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, GI gastrointestinal