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Table 1 Results from bivariate analysis on sensitivity (Sens), specificity (Spec), 95 % confidence interval (95 % CI), diagnostic odds ratio (DOR), positive/negative likelihood ratio (LR+ and LR−), and pretest and posttest probabilities

From: Predicting developmental outcomes in premature infants by term equivalent MRI: systematic review and meta-analysis

MRI test with used cut-off

Developmental outcome

No. of studies

No. of neonates

Sens (95 % CI) %

Spec (95 % CI) %

DOR

LR+

LR−

Pretest probability (%)

Posttest probability

          

Positive

Negative

WMA—“normal vs. any”

CP

1 [35]

125

100 (70–100)

81 (73–87)

>100

5.27

<0.01

7.2

29.0

<0.01

IQ

2 [36, 37]

283

79 (65–88)

41 (18–69)

2.61

1.34

0.51

16.6

21.1

9.2

Language

2 [37, 38]

283

87 (69–97)

30 (23–39)

2.78

1.24

0.44

5.3

6.5

2.4

Mental development

3 [12, 35, 39]

448

81 (59–93)

49 (26–73)

4.13

1.60

0.39

13.8

20.4

5.9

Motor

3 [12, 35, 40]

485

87 (74–94)

51 (26–76)

7.29

1.80

0.25

17.3

27.4

5.0

Vision/hearing

2 [12, 35]

125

62 (13–95)

53 (23–82)

1.88

1.33

0.71

31.2

37.6

24.4

WMA—“normal/mild vs. moderate/severe”

CP

2 [41, 42]

164

67 (38–87)

92 (85–96)

22.35

8.11

0.36

6.7

36.8

2.5

IQ

2 [36, 37]

283

53 (39–67)

83 (77–87)

5.41

3.06

0.57

16.6

37.9

10.2

Language

2 [37, 38]

283

47 (24–71)

86 (82–90)

5.46

3.38

0.62

5.3

15.9

3.4

Mental development

3 [12, 39, 41]

398

38 (26–52)

87 (83–91)

4.21

2.98

0.71

13.8

32.3

10.2

Working memory

2 [43, 44]

258

24 (17–32)

88 (78–94)

2.26

1.96

0.87

47.7

64.1

44.2

Motor

3 [12, 40, 41]

435

54 (30–77)

90 (84–94)

10.59

5.37

0.51

17.5

53.2

9.7

NDI

1 [12]

167

38 (26–53)

86 (78–91)

5.28

2.70

0.72

28.1

51.4

22.0

BA—“normal vs. any”

CP

2 [36, 45]

277

90 (68–98)

60 (54–66)

13.71

2.27

0.17

7.2

15.0

1.3

Mental development

1 [46]

180

100 (61–100)

60 (52–67)

>100

2.49

0.00

3.3

7.5

<0.01

Behavior

1 [47]

177

76 (61–88)

37 (29–46)

1.88

1.21

0.64

23.7

27.3

16.6

Hearing

2 [36, 46]

397

100 (51–100a)

58 (53–63)

>100

2.49

0.00

2.0

4.9

<0.01

NDI

2 [36, 46]

424

81 (69–89)

68 (61–75)

9.44

2.57

0.27

13.9

29.3

4.2

BA—“normal/mild vs. moderate/severe”

CP

3 [46, 48, 49]

273

90 (74–97)

80 (75–85)

37.83

4.56

0.12

11.4

36.9

0.02

Mental development

2 [46, 50]

216

82 (8–100)

75 (69–81)

13.80

3.31

0.24

8.3

23.1

0.02

Hearing

2 [36, 46]

397

100 (51–100a)

75 (70–79)

>100

3.97

<0.01

2.0

7.5

<0.01

Motor

1 [50]

34

63 (31–86)

73 (54–86a)

4.53

2.32

0.51

23.5

41.7

13.6

Behavior

1 [47]

177

33 (20–50)

78 (70–84)

1.75

1.50

0.86

23.7

31.8

21.1

NDI

3 [36, 51, 52]

405

60 (39–78)

86 (70–94)

8.96

4.17

0.47

28.2

54.0

11.7

DEHSI

CP

2 [41, 45]

421

46 (9–89)

39 (3–92)

0.55

0.76

1.38

6.2

4.8

8.3

Mental development

3 [35, 41, 53]

362

87 (72–94)

19 (9–35)

1.53

1.07

0.70

10.5

11.1

7.6

Motor

3 [35, 41, 53]

362

86 (70–94)

20 (8–40)

1.48

1.07

0.72

10.5

11.1

7.8

  1. If bivariate model could not estimate 95 % CI for pooled sensitivity for two studies, estimate is based on study with largest sample size
  2. BA brain abnormality, DEHSI diffuse excessive high signal intensity, NDI neurodevelopmental impairment, WMA white matter abnormality
  3. adata derived after contact with author
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Systematic Reviews

ISSN: 2046-4053