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Table 1 Results from bivariate analysis on sensitivity (Sens), specificity (Spec), 95 % confidence interval (95 % CI), diagnostic odds ratio (DOR), positive/negative likelihood ratio (LR+ and LR−), and pretest and posttest probabilities

From: Predicting developmental outcomes in premature infants by term equivalent MRI: systematic review and meta-analysis

MRI test with used cut-off Developmental outcome No. of studies No. of neonates Sens (95 % CI) % Spec (95 % CI) % DOR LR+ LR− Pretest probability (%) Posttest probability
           Positive Negative
WMA—“normal vs. any” CP 1 [35] 125 100 (70–100) 81 (73–87) >100 5.27 <0.01 7.2 29.0 <0.01
IQ 2 [36, 37] 283 79 (65–88) 41 (18–69) 2.61 1.34 0.51 16.6 21.1 9.2
Language 2 [37, 38] 283 87 (69–97) 30 (23–39) 2.78 1.24 0.44 5.3 6.5 2.4
Mental development 3 [12, 35, 39] 448 81 (59–93) 49 (26–73) 4.13 1.60 0.39 13.8 20.4 5.9
Motor 3 [12, 35, 40] 485 87 (74–94) 51 (26–76) 7.29 1.80 0.25 17.3 27.4 5.0
Vision/hearing 2 [12, 35] 125 62 (13–95) 53 (23–82) 1.88 1.33 0.71 31.2 37.6 24.4
WMA—“normal/mild vs. moderate/severe” CP 2 [41, 42] 164 67 (38–87) 92 (85–96) 22.35 8.11 0.36 6.7 36.8 2.5
IQ 2 [36, 37] 283 53 (39–67) 83 (77–87) 5.41 3.06 0.57 16.6 37.9 10.2
Language 2 [37, 38] 283 47 (24–71) 86 (82–90) 5.46 3.38 0.62 5.3 15.9 3.4
Mental development 3 [12, 39, 41] 398 38 (26–52) 87 (83–91) 4.21 2.98 0.71 13.8 32.3 10.2
Working memory 2 [43, 44] 258 24 (17–32) 88 (78–94) 2.26 1.96 0.87 47.7 64.1 44.2
Motor 3 [12, 40, 41] 435 54 (30–77) 90 (84–94) 10.59 5.37 0.51 17.5 53.2 9.7
NDI 1 [12] 167 38 (26–53) 86 (78–91) 5.28 2.70 0.72 28.1 51.4 22.0
BA—“normal vs. any” CP 2 [36, 45] 277 90 (68–98) 60 (54–66) 13.71 2.27 0.17 7.2 15.0 1.3
Mental development 1 [46] 180 100 (61–100) 60 (52–67) >100 2.49 0.00 3.3 7.5 <0.01
Behavior 1 [47] 177 76 (61–88) 37 (29–46) 1.88 1.21 0.64 23.7 27.3 16.6
Hearing 2 [36, 46] 397 100 (51–100a) 58 (53–63) >100 2.49 0.00 2.0 4.9 <0.01
NDI 2 [36, 46] 424 81 (69–89) 68 (61–75) 9.44 2.57 0.27 13.9 29.3 4.2
BA—“normal/mild vs. moderate/severe” CP 3 [46, 48, 49] 273 90 (74–97) 80 (75–85) 37.83 4.56 0.12 11.4 36.9 0.02
Mental development 2 [46, 50] 216 82 (8–100) 75 (69–81) 13.80 3.31 0.24 8.3 23.1 0.02
Hearing 2 [36, 46] 397 100 (51–100a) 75 (70–79) >100 3.97 <0.01 2.0 7.5 <0.01
Motor 1 [50] 34 63 (31–86) 73 (54–86a) 4.53 2.32 0.51 23.5 41.7 13.6
Behavior 1 [47] 177 33 (20–50) 78 (70–84) 1.75 1.50 0.86 23.7 31.8 21.1
NDI 3 [36, 51, 52] 405 60 (39–78) 86 (70–94) 8.96 4.17 0.47 28.2 54.0 11.7
DEHSI CP 2 [41, 45] 421 46 (9–89) 39 (3–92) 0.55 0.76 1.38 6.2 4.8 8.3
Mental development 3 [35, 41, 53] 362 87 (72–94) 19 (9–35) 1.53 1.07 0.70 10.5 11.1 7.6
Motor 3 [35, 41, 53] 362 86 (70–94) 20 (8–40) 1.48 1.07 0.72 10.5 11.1 7.8
  1. If bivariate model could not estimate 95 % CI for pooled sensitivity for two studies, estimate is based on study with largest sample size
  2. BA brain abnormality, DEHSI diffuse excessive high signal intensity, NDI neurodevelopmental impairment, WMA white matter abnormality
  3. adata derived after contact with author