|
MRI test with used cut-off
|
Developmental outcome
|
No. of studies
|
No. of neonates
|
Sens (95 % CI) %
|
Spec (95 % CI) %
|
DOR
|
LR+
|
LR−
|
Pretest probability (%)
|
Posttest probability
|
|---|
| | | | | | | | | | |
Positive
|
Negative
|
|
WMA—“normal vs. any”
|
CP
|
1 [35]
|
125
|
100 (70–100)
|
81 (73–87)
|
>100
|
5.27
|
<0.01
|
7.2
|
29.0
|
<0.01
|
|
IQ
|
2 [36, 37]
|
283
|
79 (65–88)
|
41 (18–69)
|
2.61
|
1.34
|
0.51
|
16.6
|
21.1
|
9.2
|
|
Language
|
2 [37, 38]
|
283
|
87 (69–97)
|
30 (23–39)
|
2.78
|
1.24
|
0.44
|
5.3
|
6.5
|
2.4
|
|
Mental development
|
3 [12, 35, 39]
|
448
|
81 (59–93)
|
49 (26–73)
|
4.13
|
1.60
|
0.39
|
13.8
|
20.4
|
5.9
|
|
Motor
|
3 [12, 35, 40]
|
485
|
87 (74–94)
|
51 (26–76)
|
7.29
|
1.80
|
0.25
|
17.3
|
27.4
|
5.0
|
|
Vision/hearing
|
2 [12, 35]
|
125
|
62 (13–95)
|
53 (23–82)
|
1.88
|
1.33
|
0.71
|
31.2
|
37.6
|
24.4
|
|
WMA—“normal/mild vs. moderate/severe”
|
CP
|
2 [41, 42]
|
164
|
67 (38–87)
|
92 (85–96)
|
22.35
|
8.11
|
0.36
|
6.7
|
36.8
|
2.5
|
|
IQ
|
2 [36, 37]
|
283
|
53 (39–67)
|
83 (77–87)
|
5.41
|
3.06
|
0.57
|
16.6
|
37.9
|
10.2
|
|
Language
|
2 [37, 38]
|
283
|
47 (24–71)
|
86 (82–90)
|
5.46
|
3.38
|
0.62
|
5.3
|
15.9
|
3.4
|
|
Mental development
|
3 [12, 39, 41]
|
398
|
38 (26–52)
|
87 (83–91)
|
4.21
|
2.98
|
0.71
|
13.8
|
32.3
|
10.2
|
|
Working memory
|
2 [43, 44]
|
258
|
24 (17–32)
|
88 (78–94)
|
2.26
|
1.96
|
0.87
|
47.7
|
64.1
|
44.2
|
|
Motor
|
3 [12, 40, 41]
|
435
|
54 (30–77)
|
90 (84–94)
|
10.59
|
5.37
|
0.51
|
17.5
|
53.2
|
9.7
|
|
NDI
|
1 [12]
|
167
|
38 (26–53)
|
86 (78–91)
|
5.28
|
2.70
|
0.72
|
28.1
|
51.4
|
22.0
|
|
BA—“normal vs. any”
|
CP
|
2 [36, 45]
|
277
|
90 (68–98)
|
60 (54–66)
|
13.71
|
2.27
|
0.17
|
7.2
|
15.0
|
1.3
|
|
Mental development
|
1 [46]
|
180
|
100 (61–100)
|
60 (52–67)
|
>100
|
2.49
|
0.00
|
3.3
|
7.5
|
<0.01
|
|
Behavior
|
1 [47]
|
177
|
76 (61–88)
|
37 (29–46)
|
1.88
|
1.21
|
0.64
|
23.7
|
27.3
|
16.6
|
|
Hearing
|
2 [36, 46]
|
397
|
100 (51–100a)
|
58 (53–63)
|
>100
|
2.49
|
0.00
|
2.0
|
4.9
|
<0.01
|
|
NDI
|
2 [36, 46]
|
424
|
81 (69–89)
|
68 (61–75)
|
9.44
|
2.57
|
0.27
|
13.9
|
29.3
|
4.2
|
|
BA—“normal/mild vs. moderate/severe”
|
CP
|
3 [46, 48, 49]
|
273
|
90 (74–97)
|
80 (75–85)
|
37.83
|
4.56
|
0.12
|
11.4
|
36.9
|
0.02
|
|
Mental development
|
2 [46, 50]
|
216
|
82 (8–100)
|
75 (69–81)
|
13.80
|
3.31
|
0.24
|
8.3
|
23.1
|
0.02
|
|
Hearing
|
2 [36, 46]
|
397
|
100 (51–100a)
|
75 (70–79)
|
>100
|
3.97
|
<0.01
|
2.0
|
7.5
|
<0.01
|
|
Motor
|
1 [50]
|
34
|
63 (31–86)
|
73 (54–86a)
|
4.53
|
2.32
|
0.51
|
23.5
|
41.7
|
13.6
|
|
Behavior
|
1 [47]
|
177
|
33 (20–50)
|
78 (70–84)
|
1.75
|
1.50
|
0.86
|
23.7
|
31.8
|
21.1
|
|
NDI
|
3 [36, 51, 52]
|
405
|
60 (39–78)
|
86 (70–94)
|
8.96
|
4.17
|
0.47
|
28.2
|
54.0
|
11.7
|
|
DEHSI
|
CP
|
2 [41, 45]
|
421
|
46 (9–89)
|
39 (3–92)
|
0.55
|
0.76
|
1.38
|
6.2
|
4.8
|
8.3
|
|
Mental development
|
3 [35, 41, 53]
|
362
|
87 (72–94)
|
19 (9–35)
|
1.53
|
1.07
|
0.70
|
10.5
|
11.1
|
7.6
|
|
Motor
|
3 [35, 41, 53]
|
362
|
86 (70–94)
|
20 (8–40)
|
1.48
|
1.07
|
0.72
|
10.5
|
11.1
|
7.8
|
- If bivariate model could not estimate 95 % CI for pooled sensitivity for two studies, estimate is based on study with largest sample size
- BA brain abnormality, DEHSI diffuse excessive high signal intensity, NDI neurodevelopmental impairment, WMA white matter abnormality
- adata derived after contact with author
