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Table 1 The characteristics of the studies included in the meta-analysis

From: The Epstein-Barr virus latent membrane protein-1 (LMP1) 30-bp deletion and XhoI-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies

Trial (year) Location Design NPC 30-bp del-LMP1 EBV XhoI-loss LMP1 EBV Control group
    Present Not present Type of sample Present Not present Type of sample N Type of sample Type of control
Senyuta et al. 2014 [35] Russia Case–control 4 18 Biopsy     15 PBMC HD
Gurtsevitch et al. 2013 [36] Russia Case–control 3 18 Biopsy     13 PBMC Non-NPC
Banko et al. 2012 [37] Serbia Case–control 1 15 Biopsy     30 PBMC IM
Li et al. 2009 [38] China Case–control 43 7 Biopsy     56 PBMC HD
See et al. 2008 [39] Malaysia Case–control 19 15 Biopsy 34 5 Biopsy 8 Biopsy Non-NPC
Tang et al. 2008 [40] China Cohort 18 3 Biopsy 21 0 Biopsy    
Tiwawech et al. 2008 [41] Thailand Case–control 44 31 PBL     44 PBMC Non-NPC/HD
Ayadi et al. 2007 [42] Tunisia Cohort 41 6 Biopsy 0 47 Biopsy    
Chang et al. 2006 [43] Taiwan Cohort 446 88 Biopsy       
Dardari et al. 2006 [44] Morocco Case–control 51 10 Biopsy     17 PBMC HD
Chabay et al. 2004 [45] Argentina Case–control 3 1 Biopsy     15 Biopsy/PBMC Non-NPC
Min et al. 2004 [46] China Case–control 87 12 Biopsy     46 PBMC HD
Nurhantari et al. 2003 [47] Indonesia Cohort 22 33 Biopsy       
Plaza et al. 2003 [48] Spain Case–control 18 9 Biopsy     40 - EBV-RC
Tan et al. 2003 [49] Malaysia Case–control 25 0 Biopsy 25 2 Biopsy 12 Biopsy  
Zhang et al. 2002 [50] China Case–control 36 7 Biopsy     36 TW HD
Hahn et al. 2001 [51] Russia Case–control 0 7 Biopsy     10 PBMC HD
Henry et al. 2001 [52] Tunisia Cohort 3 3 Biopsy 0 6 Biopsy    
Kuo et al. 2001 [53] Taiwan Cohort 2 0 Biopsy       
D’Addario et al. 2000 [54] Canada Cohort 9 14 Biopsy       
Cheung et al. 1998 [55] China Cohort 34 3 Biopsy       
Grunewald et al. 1998 [56] Multicenter Case–control 46 18 Biopsy     45 PBMC HD
Sung et al. 1998 [57] China Cohort 30 12 Biopsy 22 6 Biopsy    
Cheung et al. 1996 [58] China Case–control 69 5 Biopsy 5 0 Biopsy 11 Biopsy Non-NPC
Khanim et al. 1996 [29] Multicenter Case–control 24 4 Biopsy 19 9 Biopsy 14 Biopsy/PBMC Non-NPC
Chang et al. 1995 [59] Taiwan Case–control     48 0 Biopsy 25 Biopsy/TW HD
Bouzid et al. 1994 [60] North Africa Cohort     1 12 Biopsy    
Jeng et al. 1994 [61] Taiwan Case–control     25 7 Biopsy 79   Non-NPC
Miller et al. 1994 [62] Multicenter Cohort 9 4 Biopsy       
Abdel-Hamid et al. 1992 [63] Multicenter Case–control     33 18 Biopsy 19 - Non-NPC
Hu et al. 1991 [64] Multicenter Cohort     38 18 Biopsy    
  1. Abbreviations: PBMC = peripheral blood mononuclear cell; PBL = peripheral blood lymphocyte; HD = healthy donors; IM = infective mononucleosis; TW = throat washing samples; NPC = nasopharyngeal carcinoma.