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Table 1 The characteristics of the studies included in the meta-analysis

From: The Epstein-Barr virus latent membrane protein-1 (LMP1) 30-bp deletion and XhoI-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies

Trial (year)

Location

Design

NPC 30-bp del-LMP1 EBV

XhoI-loss LMP1 EBV

Control group

   

Present

Not present

Type of sample

Present

Not present

Type of sample

N

Type of sample

Type of control

Senyuta et al. 2014 [35]

Russia

Case–control

4

18

Biopsy

   

15

PBMC

HD

Gurtsevitch et al. 2013 [36]

Russia

Case–control

3

18

Biopsy

   

13

PBMC

Non-NPC

Banko et al. 2012 [37]

Serbia

Case–control

1

15

Biopsy

   

30

PBMC

IM

Li et al. 2009 [38]

China

Case–control

43

7

Biopsy

   

56

PBMC

HD

See et al. 2008 [39]

Malaysia

Case–control

19

15

Biopsy

34

5

Biopsy

8

Biopsy

Non-NPC

Tang et al. 2008 [40]

China

Cohort

18

3

Biopsy

21

0

Biopsy

   

Tiwawech et al. 2008 [41]

Thailand

Case–control

44

31

PBL

   

44

PBMC

Non-NPC/HD

Ayadi et al. 2007 [42]

Tunisia

Cohort

41

6

Biopsy

0

47

Biopsy

   

Chang et al. 2006 [43]

Taiwan

Cohort

446

88

Biopsy

      

Dardari et al. 2006 [44]

Morocco

Case–control

51

10

Biopsy

   

17

PBMC

HD

Chabay et al. 2004 [45]

Argentina

Case–control

3

1

Biopsy

   

15

Biopsy/PBMC

Non-NPC

Min et al. 2004 [46]

China

Case–control

87

12

Biopsy

   

46

PBMC

HD

Nurhantari et al. 2003 [47]

Indonesia

Cohort

22

33

Biopsy

      

Plaza et al. 2003 [48]

Spain

Case–control

18

9

Biopsy

   

40

-

EBV-RC

Tan et al. 2003 [49]

Malaysia

Case–control

25

0

Biopsy

25

2

Biopsy

12

Biopsy

 

Zhang et al. 2002 [50]

China

Case–control

36

7

Biopsy

   

36

TW

HD

Hahn et al. 2001 [51]

Russia

Case–control

0

7

Biopsy

   

10

PBMC

HD

Henry et al. 2001 [52]

Tunisia

Cohort

3

3

Biopsy

0

6

Biopsy

   

Kuo et al. 2001 [53]

Taiwan

Cohort

2

0

Biopsy

      

D’Addario et al. 2000 [54]

Canada

Cohort

9

14

Biopsy

      

Cheung et al. 1998 [55]

China

Cohort

34

3

Biopsy

      

Grunewald et al. 1998 [56]

Multicenter

Case–control

46

18

Biopsy

   

45

PBMC

HD

Sung et al. 1998 [57]

China

Cohort

30

12

Biopsy

22

6

Biopsy

   

Cheung et al. 1996 [58]

China

Case–control

69

5

Biopsy

5

0

Biopsy

11

Biopsy

Non-NPC

Khanim et al. 1996 [29]

Multicenter

Case–control

24

4

Biopsy

19

9

Biopsy

14

Biopsy/PBMC

Non-NPC

Chang et al. 1995 [59]

Taiwan

Case–control

   

48

0

Biopsy

25

Biopsy/TW

HD

Bouzid et al. 1994 [60]

North Africa

Cohort

   

1

12

Biopsy

   

Jeng et al. 1994 [61]

Taiwan

Case–control

   

25

7

Biopsy

79

 

Non-NPC

Miller et al. 1994 [62]

Multicenter

Cohort

9

4

Biopsy

      

Abdel-Hamid et al. 1992 [63]

Multicenter

Case–control

   

33

18

Biopsy

19

-

Non-NPC

Hu et al. 1991 [64]

Multicenter

Cohort

   

38

18

Biopsy

   
  1. Abbreviations: PBMC = peripheral blood mononuclear cell; PBL = peripheral blood lymphocyte; HD = healthy donors; IM = infective mononucleosis; TW = throat washing samples; NPC = nasopharyngeal carcinoma.