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Table 4 Empirical evaluation results—scenario (ii), thresholds selectively missing

From: Meta-analysis of test accuracy studies: an exploratory method for investigating the impact of missing thresholds

% PTH decrease

Estimate of interest

Meta-analysis of the complete data

Meta-analysis of the datasetswith missing threshold results, not including imputed results

Meta-analysis of the datasets with missing threshold results, including imputed results

True estimate

Mean estimate across the 1,000 datasets

Median estimate across the 1,000 datasets

Mean estimate across the 1,000 datasets

Median estimate across the 1,000 datasets

40

Summary sensitivity

0.87

0.89

0.88

0.89

0.88

0.00

0.00

0.00

0.00

0.00

s.e. (logit sensitivity)

0.40

0.52

0.48

0.52

0.48

Summary specificity

0.52

0.52

0.52

0.52

0.52

0.00

0.05

0.04

0.05

0.04

s.e. (logit specificity)

0.18

0.25

0.24

0.25

0.24

50

Summary sensitivity

0.87

0.89

0.90

0.88

0.87

0.00

0.00

0.00

0.01

0.00

s.e. (logit sensitivity)

0.40

0.53

0.52

0.46

0.44

Summary specificity

0.62

0.64

0.64

0.64

0.64

0.00

0.04

0.04

0.01

0.00

s.e. (logit specificity)

0.18

0.26

0.26

0.21

0.20

60

Summary sensitivity

0.87

0.89

0.90

0.87

0.87

0.00

0.00

0.00

0.03

0.00

s.e. (logit sensitivity)

0.40

0.52

0.48

0.44

0.40

Summary specificity

0.78

0.79

0.79

0.77

0.77

0.00

0.03

0.00

0.01

0.00

s.e. (logit specificity)

0.21

0.28

0.26

0.23

0.21

65

Summary sensitivity

0.85

0.87

0.86

0.85

0.85

0.00

0.06

0.00

0.04

0.00

s.e. (logit sensitivity)

0.38

0.54

0.49

0.41

0.38

Summary specificity

0.80

0.82

0.82

0.81

0.80

0.00

0.01

0.00

0.00

0.00

s.e. (logit specificity)

0.22

0.31

0.28

0.24

0.23

70

Summary sensitivity

0.85

0.87

0.86

0.83

0.84

0.00

0.06

0.00

0.08

0.00

s.e. (logit sensitivity)

0.38

0.54

0.49

0.41

0.38

Summary specificity

0.85

0.86

0.85

0.84

0.84

0.00

0.00

0.00

0.00

0.00

s.e. (logit specificity)

0.25

0.33

0.31

0.26

0.25

80

Summary sensitivity

0.73

0.75

0.75

0.71

0.71

0.00

0.02

0.00

0.05

0.00

s.e. (logit sensitivity)

0.30

0.45

0.41

0.37

0.34

Summary specificity

0.91

0.90

0.90

0.91

0.91

0.00

0.00

0.00

0.02

0.00

s.e. (logit specificity)

0.30

0.41

0.39

0.36

0.35

90

Summary sensitivity

0.55

0.58

0.56

0.58

0.56

0.00

0.02

0.00

0.02

0.00

s.e. (logit sensitivity)

0.27

0.41

0.37

0.41

0.37

Summary specificity

0.96

0.95

0.96

0.95

0.96

0.00

0.00

0.00

0.00

0.00

s.e. (logit specificity)

0.46

0.57

0.59

0.57

0.59

  1. NB All meta-analyses used model (2), as model (1) often poorly estimated ρ10t at +1 or -1.