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Table 4 Empirical evaluation results—scenario (ii), thresholds selectively missing

From: Meta-analysis of test accuracy studies: an exploratory method for investigating the impact of missing thresholds

% PTH decrease Estimate of interest Meta-analysis of the complete data Meta-analysis of the datasetswith missing threshold results, not including imputed results Meta-analysis of the datasets with missing threshold results, including imputed results
True estimate Mean estimate across the 1,000 datasets Median estimate across the 1,000 datasets Mean estimate across the 1,000 datasets Median estimate across the 1,000 datasets
40 Summary sensitivity 0.87 0.89 0.88 0.89 0.88
0.00 0.00 0.00 0.00 0.00
s.e. (logit sensitivity) 0.40 0.52 0.48 0.52 0.48
Summary specificity 0.52 0.52 0.52 0.52 0.52
0.00 0.05 0.04 0.05 0.04
s.e. (logit specificity) 0.18 0.25 0.24 0.25 0.24
50 Summary sensitivity 0.87 0.89 0.90 0.88 0.87
0.00 0.00 0.00 0.01 0.00
s.e. (logit sensitivity) 0.40 0.53 0.52 0.46 0.44
Summary specificity 0.62 0.64 0.64 0.64 0.64
0.00 0.04 0.04 0.01 0.00
s.e. (logit specificity) 0.18 0.26 0.26 0.21 0.20
60 Summary sensitivity 0.87 0.89 0.90 0.87 0.87
0.00 0.00 0.00 0.03 0.00
s.e. (logit sensitivity) 0.40 0.52 0.48 0.44 0.40
Summary specificity 0.78 0.79 0.79 0.77 0.77
0.00 0.03 0.00 0.01 0.00
s.e. (logit specificity) 0.21 0.28 0.26 0.23 0.21
65 Summary sensitivity 0.85 0.87 0.86 0.85 0.85
0.00 0.06 0.00 0.04 0.00
s.e. (logit sensitivity) 0.38 0.54 0.49 0.41 0.38
Summary specificity 0.80 0.82 0.82 0.81 0.80
0.00 0.01 0.00 0.00 0.00
s.e. (logit specificity) 0.22 0.31 0.28 0.24 0.23
70 Summary sensitivity 0.85 0.87 0.86 0.83 0.84
0.00 0.06 0.00 0.08 0.00
s.e. (logit sensitivity) 0.38 0.54 0.49 0.41 0.38
Summary specificity 0.85 0.86 0.85 0.84 0.84
0.00 0.00 0.00 0.00 0.00
s.e. (logit specificity) 0.25 0.33 0.31 0.26 0.25
80 Summary sensitivity 0.73 0.75 0.75 0.71 0.71
0.00 0.02 0.00 0.05 0.00
s.e. (logit sensitivity) 0.30 0.45 0.41 0.37 0.34
Summary specificity 0.91 0.90 0.90 0.91 0.91
0.00 0.00 0.00 0.02 0.00
s.e. (logit specificity) 0.30 0.41 0.39 0.36 0.35
90 Summary sensitivity 0.55 0.58 0.56 0.58 0.56
0.00 0.02 0.00 0.02 0.00
s.e. (logit sensitivity) 0.27 0.41 0.37 0.41 0.37
Summary specificity 0.96 0.95 0.96 0.95 0.96
0.00 0.00 0.00 0.00 0.00
s.e. (logit specificity) 0.46 0.57 0.59 0.57 0.59
  1. NB All meta-analyses used model (2), as model (1) often poorly estimated ρ10t at +1 or -1.