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Table 1 Summary of WHO recommended first-line antiretroviral regimens for children and adolescents[2]

From: Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol

 

Children 3 years to less than 10 years and adolescents <35 kg

Adolescents (10 to 19 years) ≥35 kg

Preferred

ABCa + 3TC + EFV

TDF + 3TC (or FTC) + EFVa

Alternatives

ABC + 3TC + NVP

 
 

AZT + 3TC + EFV

AZT + 3TC + EFV

 

AZT + 3TC + NVP

AZT + 3TC + NVP

 

TDF + 3TC (or FTC) + EFV

TDF + 3TC (or FTC) + NVP

 

TDF + 3TC (or FTC) + NVP

 

Special circumstancesc

d4Tb + 3TC + EFV

ABC + 3TC + EFV

d4Tb + 3TC + NVP

ABC + 3TC + NVP

  1. aThese recommendations apply to children and adolescents who are initiating first-line antiretroviral therapy; bd4T use should be restricted to situations in which toxicity to AZT is suspected or confirmed and access to ABC or TDF is lacking.
  2. cSpecial circumstances may include situations where preferred or alternative regimens may not be available or suitable because of significant toxicities, anticipated drug-drug interactions, drug procurement and supply management issues, or for other reasons.
  3. 3TC lamivudine, ABC abacavir, AZT zidovudine, d4T stavudine, EFV efavirenz, FTC emtricitabine, LPV/r lopinavir/ritonavir, NVP nevirapine, TDF tenofovir, WHO World Health Organization.