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Table 2 Examples of animal models of acute lung injury

From: Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol

Type of injury

Example of model

Infection in lung

Intratracheal live bacteria

Bacterial components in lung

Intratracheal endotoxin

Systemic infection

Cecal ligation and puncture

Systemic bacterial components

Systemic endotoxin

Induction by ventilator

Ventilator-induced acute lung injury

Chemical or chemotherapeutic

Oleic acid

Hydrochloric acid

Bleomycin

Shock

Hemorrhagic

Trauma

Chest trauma

Remote organ injury

Ischemia reperfusion

Pancreatitis