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Table 1 List of data items required

From: Protocol for a systematic review and individual participant data meta-analysis of B-type natriuretic peptide-guided therapy for heart failure

Type of data  
Study level Country in which study was carried out
  Number of participants randomized
  Number allocated to the BNP group
  Number allocated to the standard care group
  Setting (primary care, hospitals, specialist clinics)
  Date first patient randomized
  Date final patient randomized
  Date of final follow-up
  Did the study measure quality of life (state tool that was used)
  Did the study measure heart failure risk score (state tool that was used)
  Details of intervention (frequency of testing, actions, etc.)
  Details of comparator (frequency of review, actions, etc.)
Individual participant Variables collected at study entry
Demography Age
  Sex
  Body mass index (or weight and height)
  Smoking status
  Date of entry into study/date of randomization
  Allocated to BNP or standard care
  Centre if multi centre
Medical history Cause of heart failure
  Previous myocardial infarction
  Previous intervention (PCI/CABG)
  Previous stroke
  Previous angina pectoris
  Previous peripheral artery disease
  Diabetes status (including type)
  History of hypertension
  History of atrial fibrillation
  History of chronic obstructive pulmonary disease
  Pacemaker in situ
  Implantable cardioverter defibrillator in situ
  Heart failure risk score (if measured)
Individual participant Variables collected at each visit (data required for all visits including baseline visit)
  Date of visit
Clinical NYHA class
  Left ventricular ejection fraction
  Resting heart rate
  Systolic blood pressure
  Diastolic blood pressure
  Heart failure score
Laboratory BNP/NT-BNP
  Creatinine
  Sodium
  Potassium
  Blood urea nitrogen
  Haemoglobin
Drug treatment ACE inhibitors
  Angiotensin receptor blockers
  Beta-blockers
  Mineralocorticoid receptor antagonists
  Loop diuretic
  Thiazide diuretics
  Vasodilator
  Other potassium sparing diuretic
  Aspirin
  Other anti-platelet agent
  Oral anticoagulant
  Digoxin
  Amiodarone
  Other anti-arrhythmic
  Calcium-channel blocker
  Statin
Quality of life If collected (derived scores if available)
Individual participant Clinical outcomes (data required for all deaths, hospital admissions or cardiovascular events)
  Date of death
  Cause of death
  Date of hospital admission/cardiovascular event
  Date of hospital discharge
  Details of reason for admission/cardiovascular event (for example heart failure, non fatal myocardial infarction, non-fatal stroke, new atrial fibrillation, fitting of pacemaker/CRT device/implantable cardioverter defibrillator)
Lost to follow-up? Date of last follow-up
  1. ACE, angiotensin-converting enzyme; CABG, coronary artery bypass grafting CRT, cardiac resynchronization therapy; BNP, B-type natriuretic peptide; NT-BNP, N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart Association; PCI, percutaneous coronary intervention.