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Table 1 Default risk ratios (RR) assigned to unpublished studies with binary outcomes

From: SAMURAI: Sensitivity analysis of a meta-analysis with unpublished but registered analytical investigations (software)

Outlook Depends on published studies? If the outcome event is desired (higher.is.better = T) If the outcome event is undesired (higher.is.better = F)
‘very positive’ No 3 0.33
‘positive’ 2 0.5
‘no effect’ 1 1
‘negative’ 0.5 2
‘very negative’ 0.33 3
‘very positive CL’ Yes, depends on CL of published studies UCL pub,1-α LCL pub,1-α
‘positive CL’ 0.5 RR ^ pub + UC L pub , 1 a 0.5 RR ^ pub + LC L pub , 1 a
‘current effect’ RR ^ pub RR ^ pub
‘negative CL’ 0.5 RR ^ pub + LC L pub , 1 a 0.5 RR ^ pub + UC L pub , 1 a
‘very negative CL’ LCL pub,1-α UCL pub,1-α
  1. Note: ‘Positive’ outlooks favor the experimental treatment arm and ‘negative’ outlooks favor the control treatment arm.
  2. RR: Risk ratio, or relative risk.
  3. LCL: Lower confidence limit.
  4. UCL: Upper confidence limit. RR ^ pub : The summary RR across all published studies.
  5. LCL pub,1-α ,UCL pub,1-α : The 1-α confidence interval of RR ^ pub .