A01
|
Andrade
|
1991
|
N
|
44
|
33
|
N
|
25.0
|
Ritchie articular index
|
Continuous
|
6 months
|
A05
|
Bell
|
2004
|
Y
|
62
|
53
|
Y
|
14.5
|
Tender point pain on palpation
|
Continuous
|
3 months
|
A06
|
Bonne
|
2003
|
N
|
44
|
39
|
N
|
11.4
|
Hamilton Rating Scale for Anxiety (HAM-A)
|
Continuous
|
10 weeks
|
A07
|
Brien
|
2011
|
N
|
32
|
23
|
N
|
28.1
|
Proportion of patients meeting ACR 20% improvement criteria (‘ACR20 response’)
|
Dichotomous
|
28 weeks
|
A09
|
Cavalcanti
|
2003
|
N
|
28
|
20
|
N
|
28.6
|
Responders: patients with more than 50% reduction in pruritus score
|
Dichotomous
|
60 days
|
A10
|
Chapman
|
1999
|
Y
|
61
|
50
|
Y
|
18.0
|
SRH-SLPD functional assessment tool: SRS (symptoms) sub-scale
|
Continuous
|
4 months
|
A11
|
de Lange de Klerk
|
1994
|
N
|
175
|
170
|
Y
|
2.9
|
Daily total symptom score
|
Continuous
|
1 year
|
A13
|
Fisher
|
2006
|
Y
|
38
|
27
|
N
|
28.9
|
VAS of overall symptom severity
|
Continuous
|
13 weeks
|
A14
|
Frass
|
2005
|
N
|
70
|
67
|
Y
|
4.3
|
Patient survival
|
Dichotomous
|
180 days
|
A16
|
Gaucher
|
1994
|
N
|
80
|
51
|
Y
|
36.3
|
Degree of dehydration
|
Continuous
|
12 h
|
A18
|
Jacobs
|
1993
|
N
|
34
|
33
|
N
|
2.9
|
Number of days until fewer than 3 unformed stools for 2 consecutive days
|
Continuous
|
Up to 6 days
|
A19
|
Jacobs
|
1994
|
N
|
92
|
81
|
Y
|
12.0
|
Number of days until fewer than 3 unformed stools for 2 consecutive days
|
Continuous
|
Up to 5 days
|
A20
|
Jacobs
|
2001
|
Y
|
75
|
75
|
Y
|
0.0
|
Treatment failure
|
Dichotomous
|
5 days (cumulative total)
|
A21
|
Jacobs
|
2000
|
N
|
126
|
116
|
Y
|
7.9
|
Number of days until fewer than 3 unformed stools for 2 consecutive days
|
Continuous
|
5 days
|
A22
|
Jacobs
|
2005b
|
Y
|
53
|
33
|
N
|
37.7
|
Hot flash severity score
|
Continuous
|
12 months
|
A23
|
Jacobs
|
2005a
|
Y
|
43
|
37
|
N
|
14.0
|
Conners Global Index–Parent (CGI-P)—total
|
Continuous
|
17 weeks
|
A24
|
Jansen
|
1992
|
Y
|
10
|
4
|
N
|
60.0
|
Endoscopic appearance (grade)
|
Continuous
|
12 months
|
A25
|
Kainz
|
1996
|
N
|
67
|
60
|
Y
|
10.4
|
Responders: patients with at least 50% reduction in area of skin affected by warts
|
Dichotomous
|
8 weeks
|
A26
|
Katz
|
2005
|
Y
|
7
|
3
|
N
|
57.1
|
Hamilton Depression Scale (HAMD)
|
Continuous
|
12 weeks
|
A30
|
Naudé
|
2010
|
N
|
33
|
30
|
N
|
9.1
|
Sleep Impairment Index (SII) summary score
|
Continuous
|
4 weeks
|
A31
|
Rastogi ( a)
|
1999
|
N
|
50
|
42
|
N
|
16.0
|
CD4+ T-lymphocyte counts
|
Continuous
|
6 months
|
A31
|
Rastogi ( b)
|
1999
|
N
|
50
|
38
|
N
|
24.0
|
CD4+ T-lymphocyte counts
|
Continuous
|
6 months
|
A32
|
Sajedi
|
2008
|
N
|
24
|
16
|
N
|
33.3
|
Modified Ashworth Scale: measurement of muscle tone in right leg
|
Continuous
|
4 months
|
A33
|
Siebenwirth
|
2009
|
N
|
24
|
14
|
N
|
41.7
|
MP (multiparameter dermatitis) score
|
Continuous
|
32 weeks
|
A34
|
Steinsbekk
|
2005
|
N
|
251
|
199
|
Y
|
20.7
|
Parent-reported URTI total symptom score
|
Continuous
|
Duration of 12 weeks
|
A35
|
Straumsheim
|
2000
|
N
|
73
|
68
|
Y
|
6.8
|
Frequency of migraine attacks per month
|
Continuous
|
Last month of 4-month period
|
A36
|
Thompson
|
2005
|
Y
|
53
|
45
|
Y
|
15.1
|
MYMOP profile score
|
Continuous
|
16 weeks
|
A37
|
Walach
|
1997
|
N
|
98
|
92
|
Y
|
6.1
|
Frequency of headaches per month
|
Continuous
|
Last month of 3-month period
|
A38
|
Weatherley- Jones
|
2004
|
N
|
103
|
86
|
Y
|
16.5
|
Responders: those with clinical improvement (Multidimensional Fatigue Inventory: mental fatigue)
|
Dichotomous
|
7 months
|
A39
|
White
|
2003
|
N
|
89
|
74
|
Y
|
16.9
|
Childhood Asthma Questionnaire (CAQ) sub-scale for severity of symptoms
|
Continuous
|
52 weeks
|
A40
|
Whitmarsh
|
1997
|
N
|
63
|
60
|
Y
|
4.8
|
Frequency of migraine attacks per month
|
Continuous
|
Last month of 4-month period
|
A41
|
Yakir
|
2001
|
Y
|
23
|
19
|
N
|
17.4
|
Menstrual distress questionnaire (MDQ) score
|
Continuous
|
Duration of 3 months (last 7 days per cycle)
|