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Table 3 Relevant data extraction information

From: Efficacy and safety of damage control in experimental animal models of injury: protocol for a systematic review and meta-analysis

Data extraction category Specific information to extract
Study characteristics Author(s); year of publication, study design (randomized controlled trial or prospective cohort).
Characteristics of animal model Species; strain; gender; total number of animals; number of animals in each experimental cohort; number of animals excluded; age (in total and per experimental cohort); weight (in total and per experimental cohort); and physiological characteristics reported by the authors at baseline before application of interventions (in total and per experimental cohort).
Details of injury induced in animals Specifics of the injury that was induced; mechanism of producing the injury model (as described by authors); anatomical location of the injury or injuries (e.g., polytrauma model vs. single/more localized type of injury); and injury severity (e.g., specific grade of liver injury).
Details of treatment employed Whether an entire damage control paradigm or an individual intervention or adjunct was tested; the specific treatment that was evaluated; and the definition of damage control surgery. Additional details collected are based on a modified version of the elements of experimental procedures outlined in the Animal Research: Reporting In Vivo Experiments (ARRIVE) guidelines: how, when, where, and why[66]: How? Specific method of employment of treatment tested and how long it was applied for. When? How long after injury was induced was the intervention(s)/adjunct(s) implemented? Where? Laboratory setting, surgical theater, or alternate setting as described by author(s). Why? To evaluate the purpose of testing the treatment.
Consequences of damage control surgery and/or definitive surgery to animals Mortality; changes in post-injury physiological parameters, including estimated volumes and/or rates of blood loss, laboratory surrogates of blood loss (complete blood counts, hemoglobin concentrations, and/or hematocrits); and several physiologic measurements, including blood pressures (mean arterial (MAP), systolic, and diastolic), heart rates, urinary outputs, and core body temperatures, and arterial lactate, base deficit/excess, and pH values, prothrombin and partial thromboplastin times, international normalized ratios, and thromboelastography (TEG) results/activated clotting times.