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Table 1 Outline of risk of bias assessment
| Aspect of trial bias assessed | Type of risk of bias in trial and clarification |
|---|---|
| 1. Random sequence generation | Selection bias |
| 2. Allocation concealment | Selection bias |
| 3. Blinding of participants and personnel | Performance bias |
| 4a. Blinding of outcome assessment - subjective outcomes | Detection bias; e.g. depression symptoms measured on a standardized self-report questionnaire |
| 4b. Blinding of outcome assessment - objective outcomes | Detection bias; e.g. depression remission measured by a structured clinical interview |
| 5. Incomplete outcome data | Attrition bias |
| 6. Selective reporting | Reporting bias |
| 7. Other bias | e.g. when bias may seriously alter the results, such as improper adjustment for baseline imbalances or funding bias |
