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Table 1 Outline of risk of bias assessment

From: Collaborative care for the treatment of comorbid depression and coronary heart disease: a systematic review and meta-analysis protocol

Aspect of trial bias assessed Type of risk of bias in trial and clarification
1. Random sequence generation Selection bias
2. Allocation concealment Selection bias
3. Blinding of participants and personnel Performance bias
4a. Blinding of outcome assessment - subjective outcomes Detection bias; e.g. depression symptoms measured on a standardized self-report questionnaire
4b. Blinding of outcome assessment - objective outcomes Detection bias; e.g. depression remission measured by a structured clinical interview
5. Incomplete outcome data Attrition bias
6. Selective reporting Reporting bias
7. Other bias e.g. when bias may seriously alter the results, such as improper adjustment for baseline imbalances or funding bias