|
Fibrosis test (cutoff)
|
Number of samples
|
Sensitivity (median, range)
|
Specificity (median, range)
|
Positive likelihood ratio (median, range)
|
Negative likelihood ratio (median, range)
|
|---|
|
Platelets <140 to <155
|
9
|
0.78 (0.41–0.93)
|
0.87 (0.84–0.94)
|
6.0 (2.8–93)
|
0.25 (0.07–0.63)
|
|
With additional data
|
10a
|
0.77 (0.41–0.93)
|
0.86 (0.57–0.99)
|
5.5 (1.6–93)
|
0.27 (0.07–0.63)
|
|
API ≥6.0
|
5/3b
|
0.67 (0.43–0.80)
|
0.87 (0.81–0.93)
|
5.2 (2.7–10)
|
0.38 (0.22–0.68)
|
|
With additional data
|
6a
|
0.64 (0.12–0.80)
|
0.88 (0.81–0.99)
|
5.3 (2.7–17)
|
0.41 (0.22–0.88)
|
|
APRI >1.0 or ≥1.0
|
19
|
0.77 (0.33–1.0)
|
0.75 (0.30–0.87)
|
3.1 (1.4–4.9)
|
0.31 (0–0.77)
|
|
With additional data
|
30/29b,c
|
0.75 (0.13–1.0)
|
0.77 (0.30–1.0)
|
3.2 (1.4–10.6)
|
0.33 (0–0.89)
|
|
AST: ALT ratio >1.0
|
17
|
0.36 (0.12–0.78)
|
0.92 (0.59–1.0)
|
4.5 (1.0
–
31)
|
0.70 (0.47–1.0)
|
|
With additional data
|
19a
|
0.39 (0.10–0.78)
|
0.93 (0.59–1.0)
|
5.6 (1.0
–
31)
|
0.66 (0.23–1.0)
|
|
FIB-4 > 1.45
|
1
|
0.90
|
0.58
|
2.1
|
0.17
|
|
With additional data
|
4c
|
0.89 (0.87–1.0)
|
0.58 (0.40–0.70)
|
2.1 (1.7–2.9)
|
0.19 (0.0–0.23)
|
|
FIB-4 > 3.25
|
1
|
0.55
|
0.92
|
6.9
|
0.49
|
|
With additional data
|
5c
|
0.49 (0.40–0.55)
|
0.93 (0.91–0.95)
|
6.4 (5.7–8.9)
|
0.60 (0.49–0.63)
|
|
FibroTest >0.56 or >0.66
|
2
|
0.85 and 0.82
|
0.74 and 0.77
|
3.3 and 36
|
0.20 and 0.23
|
|
With additional data
|
7c
|
0.83 (0.27–0.91)
|
0.74 (0.65–1.0)
|
3.6 (2.6–3.6)
|
0.23 (0.11–0.73)
|
|
FibroTest >0.73, >0.75, >0.862
|
7
|
0.56 (0.30–1.0)
|
0.81 (0.24–0.96)
|
2.9 (1.2–10)
|
0.54 (0.0–0.79)
|
|
With additional data
|
10a,c
|
0.49 (0.11–0.86)
|
0.89 (0.55–1.0)
|
4.3 (1.2–11)
|
0.57 (0.20–0.89)
|
|
Forns Index >4.2
|
1
|
0.98
|
0.27
|
1.3
|
0.07
|
|
With additional data
|
6c
|
0.66 (0.27–1.0)
|
0.31 (0–1.0)
|
1.4 (0.27–1.5)
|
0.07 (0–0.66)
|
|
Forns Index >6.9
|
1
|
0.67
|
0.91
|
7.4
|
0.36
|
|
With additional data
|
3c
|
0.66 (0.53–0.67)
|
0.87 (0.86–0.91)
|
5.2 (4.2–7.4)
|
0.39 (0.36–0.53)
|
|
Lok Index ≥0.20 or >0.26
|
6
|
0.90 (0.67–1.0)
|
0.50 (0.30–0.82)
|
1.8 (1.0–4.8)
|
0.21 (0–0.94)
|
|
With additional data
|
7c
|
0.90 (0.67–1.0)
|
0.53 (0.30–0.82)
|
1.9 (1.0–4.8)
|
0.19 (0–0.94)
|
|
Lok Index ≥0.5 or >0.6
|
7
|
0.53 (0.40–0.79)
|
0.88 (0.60–0.95)
|
4.4 (1.3
–
11)
|
0.53 (0.24–0.80)
|
|
With additional data
|
8c
|
0.53 (0.23–0.79)
|
0.91 (0.60–0.97)
|
5.8 (1.3
–
11)
|
0.52 (0.24–0.80)
|
- Values in italics indicate a change to above or below a cutoff of 5.0 for positive likelihood ratio or 0.20 for negative likelihood ratio.
-
ALT serum alanine aminotransferase, API age platelet index, APRI aspartate aminotransferase to platelet ratio index, AST aspartate aminotransferase.
-
aAdditional data for study(s) with discrepancy in reported data.
-
bThe first number is the number of samples for sensitivity/the second number is the number of samples for specificity.
-
cAdditional data for study(s) without 2 × 2 tables.
