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Table 2 Diagnostic accuracy of tests for fibrosis

From: Impact of contacting study authors to obtain additional data for systematic reviews: diagnostic accuracy studies for hepatic fibrosis

Fibrosis test (cutoff) Number of samples Sensitivity (median, range) Specificity (median, range) Positive likelihood ratio (median, range) Negative likelihood ratio (median, range)
Platelets <140 to <163 8 0.56 (0.28–0.89) 0.91 (0.69–1.0) 6.3 (2.3–14) 0.48 (0.16–0.78)
 With additional data 10a 0.57 (0.28–0.89) 0.91 (0.58–1.0) 6.3 (1.64–35) 0.48 (0.16–0.78)
API >3.5 or ≥4.0 5 0.70 (0.52–0.82) 0.70 (0.51–0.77) 2.3 (1.7–2.7) 0.43 (0.34–0.67)
 With additional data 6a 0.64 (0.52–0.82) 0.69 (0.51–0.77) 2.0 (1.7–2.7) 0.53 (0.34–0.67)
API ≥6.0 5/3b 0.51 (0.19–0.75) 0.90 (0.58–0.96) 5.1 (1.8 – 7.3) 0.54 (0.43–0.94)
 With additional data 6a 0.54 (0.19–0.75) 0.88 (0.58–0.96) 4.5 (1.4 – 7.3) 0.52 (0.43–0.94)
APRI ≥0.5 to >0.55 28 0.81 (0.29–0.98) 0.55 (0.10–0.94) 1.8 (1.1–4.8) 0.35 (0.08–0.78)
 With additional data 40c 0.79 (0.29–0.98) 0.56 (0.10–1.0) 1.8 (1.0–7.5) 0.56 (0.07–0.93)
AST: ALT ratio >1.0 5 0.35 (0.08–0.45) 0.77 (0.62–1.0) 1.5 (1.1–15) 0.84 (0.84–0.98)
 With additional data 8a,c 0.36 (0.08–0.59) 0.80 (0.48–1.0) 1.7 (1.1–14) 0.81 (0.65–0.98)
ELF >8.75, >9.0, or >9.78 3 0.85 (0.84–0.86) 0.70 (0.62–0.80) 2.8 (2.3–4.2) 0.21 (0.19–0.23)
 With additional data 3a 0.84 (0.62–0.85) 0.80 (0.70–0.86) 4.2 (2.8–4.4) 0.20 (0.19–0.45)
FIB-4 > 1.26 or ≥1.45 6 0.64 (0.62–0.86) 0.68 (0.54–0.75) 2.0 (0.88–2.6) 0.53 (0.21–1.3)
 With additional data 9c 0.64 (0.57–0.86) 0.68 (0.28–0.85) 2.0 (0.88–3.7) 0.53 (0.21–1.3)
FIB-4 > 3.25 4 0.50 (0.28–0.86) 0.79 (0.59–0.99) 2.4 (1.3 – 28) 0.63 (0.21–0.80)
 With additional data 7c 0.28 (0.11–0.86) 0.97 (0.59–1.0) 9.3 (1.3 – 28) 0.74 (0.21–0.89)
FibroIndex >1.25 3 0.94 (0.62–0.97) 0.40 (0.40–0.48) 1.6 (1.2–1.6) 0.15 (0.08 – 0.79)
 With additional data 6c 0.64 (0.54–0.97) 0.57 (0.40–1.0) 1.5 (1.2–2.2) 0.62 (0.08 – 0.79)
FibroIndex >2.25 or ≥2.25 3 0.30 (0.17–0.36) 0.97 (0.97–1.0) 10,12,∞ 0.72 (0.66–0.83)
 With additional data 4c 0.24 (0.14–0.36) 0.99 (0.97–1.0) 10,12,∞ 0.78 (0.66–0.87)
FibroMeter >0.419 to >0.59 3 0.69 (0.64–0.80) 0.81 (0.76–0.81) 3.6 (3.4–3.6) 0.38 (0.26–0.44)
 With additional data 5c 0.80 (0.64–0.87) 0.76 (0.64–0.81) 3.3 (2.4–3.6) 0.26 (0.21–0.44)
FibroTest >0.10 to >0.22 6 0.92 (0.88–0.97) 0.38 (0.27–0.56) 1.5 (1.3–1.9) 0.21 (0.11 – 0.28)
 With additional data 9c 0.92 (0.64–0.98) 0.46 (0.21–1.0) 1.7 (1.2–2.2) 0.17 (0.11 – 0.39)
FibroTest >0.70 or >0.80 5 0.22 (0.20–0.50) 0.96 (0.95–0.98) 5.5 (5.5–13) 0.81 (0.53–0.82)
 With additional data 10a,c 0.38 (0.20–0.94) 0.95 (0.36–0.98) 7.6 (1.4–13) 0.65 (0.12–0.82)
Forns Index >4.2 to >4.57 14 0.88 (0.57–0.94) 0.52 (0.20–0.77) 1.8 (1.2–2.2) 0.22 (0.12–0.64)
 With additional data 16a,c 0.89 (0.42–0.94) 0.51 (0.20–0.77) 1.8 (0.54–2.2) 0.23 (0.12–2.6)
Forns Index >6.9 10 0.36 (0.18–0.61) 0.94 (0.66–1.0) 6.5 (1.6–18) 0.68 (0.56–0.92)
 With additional data 14c 0.40 (0.18–0.81) 0.95 (0.33–1.0) 7.4 (1.2–18) 0.63 (0.22–0.92)
Hepascore >0.46 to ≥0.55 5 0.66 (0.54–0.82) 0.79 (0.65–0.86) 3.1 (2.3–4.5) 0.43 (0.28–0.55)
 With additional data 8c 0.65 (0.54–0.82) 0.80 (0.65–0.86) 3.2 (2.3–4.5) 0.44 (0.28–0.55)
Lok Index >0.17 or >0.20 0 NA NA NA NA
 With additional data 3c 0.58 (0.48–0.82) 0.80 (0.58–0.81) 2.9 (2.0–3.1) 0.53 (0.31–0.65)
  1. Values in italics indicate a change to above or below a cutoff of 5.0 for positive likelihood ratio or 0.20 for negative likelihood ratio.
  2. ALT serum alanine aminotransferase, API age platelet index, APRI aspartate aminotransferase to platelet ratio index, AST aspartate aminotransferase, ELF enhanced liver fibrosis, NA not available.
  3. aAdditional data for study(s) with discrepancy in reported data.
  4. bThe first number is the number of samples for sensitivity/the second number is the number of samples for specificity.
  5. cAdditional data for study(s) without 2 × 2 tables.
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Systematic Reviews

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