|
Fibrosis test (cutoff)
|
Number of samples
|
Sensitivity (median, range)
|
Specificity (median, range)
|
Positive likelihood ratio (median, range)
|
Negative likelihood ratio (median, range)
|
|---|
|
Platelets <140 to <163
|
8
|
0.56 (0.28–0.89)
|
0.91 (0.69–1.0)
|
6.3 (2.3–14)
|
0.48 (0.16–0.78)
|
|
With additional data
|
10a
|
0.57 (0.28–0.89)
|
0.91 (0.58–1.0)
|
6.3 (1.64–35)
|
0.48 (0.16–0.78)
|
|
API >3.5 or ≥4.0
|
5
|
0.70 (0.52–0.82)
|
0.70 (0.51–0.77)
|
2.3 (1.7–2.7)
|
0.43 (0.34–0.67)
|
|
With additional data
|
6a
|
0.64 (0.52–0.82)
|
0.69 (0.51–0.77)
|
2.0 (1.7–2.7)
|
0.53 (0.34–0.67)
|
|
API ≥6.0
|
5/3b
|
0.51 (0.19–0.75)
|
0.90 (0.58–0.96)
|
5.1 (1.8
–
7.3)
|
0.54 (0.43–0.94)
|
|
With additional data
|
6a
|
0.54 (0.19–0.75)
|
0.88 (0.58–0.96)
|
4.5 (1.4
–
7.3)
|
0.52 (0.43–0.94)
|
|
APRI ≥0.5 to >0.55
|
28
|
0.81 (0.29–0.98)
|
0.55 (0.10–0.94)
|
1.8 (1.1–4.8)
|
0.35 (0.08–0.78)
|
|
With additional data
|
40c
|
0.79 (0.29–0.98)
|
0.56 (0.10–1.0)
|
1.8 (1.0–7.5)
|
0.56 (0.07–0.93)
|
|
AST: ALT ratio >1.0
|
5
|
0.35 (0.08–0.45)
|
0.77 (0.62–1.0)
|
1.5 (1.1–15)
|
0.84 (0.84–0.98)
|
|
With additional data
|
8a,c
|
0.36 (0.08–0.59)
|
0.80 (0.48–1.0)
|
1.7 (1.1–14)
|
0.81 (0.65–0.98)
|
|
ELF >8.75, >9.0, or >9.78
|
3
|
0.85 (0.84–0.86)
|
0.70 (0.62–0.80)
|
2.8 (2.3–4.2)
|
0.21 (0.19–0.23)
|
|
With additional data
|
3a
|
0.84 (0.62–0.85)
|
0.80 (0.70–0.86)
|
4.2 (2.8–4.4)
|
0.20 (0.19–0.45)
|
|
FIB-4 > 1.26 or ≥1.45
|
6
|
0.64 (0.62–0.86)
|
0.68 (0.54–0.75)
|
2.0 (0.88–2.6)
|
0.53 (0.21–1.3)
|
|
With additional data
|
9c
|
0.64 (0.57–0.86)
|
0.68 (0.28–0.85)
|
2.0 (0.88–3.7)
|
0.53 (0.21–1.3)
|
|
FIB-4 > 3.25
|
4
|
0.50 (0.28–0.86)
|
0.79 (0.59–0.99)
|
2.4 (1.3
–
28)
|
0.63 (0.21–0.80)
|
|
With additional data
|
7c
|
0.28 (0.11–0.86)
|
0.97 (0.59–1.0)
|
9.3 (1.3
–
28)
|
0.74 (0.21–0.89)
|
|
FibroIndex >1.25
|
3
|
0.94 (0.62–0.97)
|
0.40 (0.40–0.48)
|
1.6 (1.2–1.6)
|
0.15 (0.08
–
0.79)
|
|
With additional data
|
6c
|
0.64 (0.54–0.97)
|
0.57 (0.40–1.0)
|
1.5 (1.2–2.2)
|
0.62 (0.08
–
0.79)
|
|
FibroIndex >2.25 or ≥2.25
|
3
|
0.30 (0.17–0.36)
|
0.97 (0.97–1.0)
|
10,12,∞
|
0.72 (0.66–0.83)
|
|
With additional data
|
4c
|
0.24 (0.14–0.36)
|
0.99 (0.97–1.0)
|
10,12,∞
|
0.78 (0.66–0.87)
|
|
FibroMeter >0.419 to >0.59
|
3
|
0.69 (0.64–0.80)
|
0.81 (0.76–0.81)
|
3.6 (3.4–3.6)
|
0.38 (0.26–0.44)
|
|
With additional data
|
5c
|
0.80 (0.64–0.87)
|
0.76 (0.64–0.81)
|
3.3 (2.4–3.6)
|
0.26 (0.21–0.44)
|
|
FibroTest >0.10 to >0.22
|
6
|
0.92 (0.88–0.97)
|
0.38 (0.27–0.56)
|
1.5 (1.3–1.9)
|
0.21 (0.11
–
0.28)
|
|
With additional data
|
9c
|
0.92 (0.64–0.98)
|
0.46 (0.21–1.0)
|
1.7 (1.2–2.2)
|
0.17 (0.11
–
0.39)
|
|
FibroTest >0.70 or >0.80
|
5
|
0.22 (0.20–0.50)
|
0.96 (0.95–0.98)
|
5.5 (5.5–13)
|
0.81 (0.53–0.82)
|
|
With additional data
|
10a,c
|
0.38 (0.20–0.94)
|
0.95 (0.36–0.98)
|
7.6 (1.4–13)
|
0.65 (0.12–0.82)
|
|
Forns Index >4.2 to >4.57
|
14
|
0.88 (0.57–0.94)
|
0.52 (0.20–0.77)
|
1.8 (1.2–2.2)
|
0.22 (0.12–0.64)
|
|
With additional data
|
16a,c
|
0.89 (0.42–0.94)
|
0.51 (0.20–0.77)
|
1.8 (0.54–2.2)
|
0.23 (0.12–2.6)
|
|
Forns Index >6.9
|
10
|
0.36 (0.18–0.61)
|
0.94 (0.66–1.0)
|
6.5 (1.6–18)
|
0.68 (0.56–0.92)
|
|
With additional data
|
14c
|
0.40 (0.18–0.81)
|
0.95 (0.33–1.0)
|
7.4 (1.2–18)
|
0.63 (0.22–0.92)
|
|
Hepascore >0.46 to ≥0.55
|
5
|
0.66 (0.54–0.82)
|
0.79 (0.65–0.86)
|
3.1 (2.3–4.5)
|
0.43 (0.28–0.55)
|
|
With additional data
|
8c
|
0.65 (0.54–0.82)
|
0.80 (0.65–0.86)
|
3.2 (2.3–4.5)
|
0.44 (0.28–0.55)
|
|
Lok Index >0.17 or >0.20
|
0
|
NA
|
NA
|
NA
|
NA
|
|
With additional data
|
3c
|
0.58 (0.48–0.82)
|
0.80 (0.58–0.81)
|
2.9 (2.0–3.1)
|
0.53 (0.31–0.65)
|
- Values in italics indicate a change to above or below a cutoff of 5.0 for positive likelihood ratio or 0.20 for negative likelihood ratio.
-
ALT serum alanine aminotransferase, API age platelet index, APRI aspartate aminotransferase to platelet ratio index, AST aspartate aminotransferase, ELF enhanced liver fibrosis, NA not available.
-
aAdditional data for study(s) with discrepancy in reported data.
-
bThe first number is the number of samples for sensitivity/the second number is the number of samples for specificity.
-
cAdditional data for study(s) without 2 × 2 tables.
