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Table 1 Defined search strategy for the extraction of pertinent studies from multiple databases

From: The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol

CINAHL search strategy search = ___ 1. (MH ‘methadone+’)
2. (MH ‘suboxone+’)
3. (MH ‘heroin assisted treatment+’)
4. (MH ‘diacetylmorphine+’)
5. (MH ‘heroin adjusted therapy+’)
6. (MH ‘buprenorphine+’)
7. (MH ‘Revia+’)
8. (MH ‘Depade+’)
9. (MH ‘Naltrexone+’)
10. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9
11. (MH ‘disorder, substance abuse’) or (MH ‘substance withdrawal syndrome+’) or (MH ‘substitute opioid therapy+’)
12. 10 AND 11
Medline search strategy search = ____ 1. methadone/th [Therapy]
2. limit 1 to humans
3. opioid substitution treatment/ae mo [adverse effects, mortality]
4. limit 3 to humans
5. substance-Related Disorders/de, ep, th [Drug Effects, Epidemiology, Therapy]
6. Limit 5 to humans
7. Opiate Substitution Treatment/or Naloxone/or Buprenorphine/or Opioid-Related Disorders/or Heroin Dependence/or Substance Withdrawal Syndrome/or Narcotic Antagonists/
8. Limit 7 to humans
9. Naltrexone/ae, ag, ai, tu [Adverse Effects, Agonists, Antagonists & Inhibitors, Therapeutic Use]
10. Limit 9 to humans
11. Substance Abuse Treatment Centers/or Substance Abuse, Intravenous/or Heroin/or Heroin Dependence/or Opioid-Related Disorders/or Randomized Controlled Trials as Topic/or Methadone/
12. Limit 11 to humans
13. methadone/
14. limit 13 to humans
15. 2 OR 4 OR 8 OR 10 OR 12 OR 14
16. 15 AND 6
Web of science search strategy search = _____ 1. Topic = (‘methadone’ OR ‘methadone maintenance therapy’ OR ‘naltrexone’ OR ‘suboxone’ OR ‘buprenorphine’ OR ‘heroin assisted treatment’)
2. Topic = (‘substitute opioid therapy’ OR ‘opioid substitution therapy’)
3. 1 AND 2
EMBASE search strategy Search = ___ 1. methadone treatment/or methadone/or methadone plus naloxone/
2. limit 1 to human
3. buprenorphine plus naloxone/
4. limit 3 to human
5. morphine sulfate plus naltrexone/or naltrexone/
6. limit 5 to human
7. opiate addiction/or heroin dependence/or methadone/or diamorphine/
8. limit 7 to human
9. opiate substitution treatment/ae [Adverse Drug Reaction]
10. methadone/or buprenorphine/or opiate addiction/or substitute opioid therapy.mp.
11. 9 or 10
12. 2 or 4 or 6 or 8
13. 11 and 12
14. substance abuse/or addiction/or drug dependence/
15. 13 and 14
16. randomized controlled trial/
17. 15 and 16
PsycINFO search strategy search = _____ 1. exp Methadone Maintenance/or exp Methadone/
2. limit 1 to human
3. exp Treatment Outcomes/or exp Drug Therapy/or exp Methadone Maintenance/or exp Drug Dependency/or exp Maintenance Therapy/or exp Methadone/or exp Heroin/
4. limit 3 to human
5. exp Drug Addiction/or exp Clinics/or exp Drug Therapy/or exp Drug Dependency/or exp ‘Recovery (Disorders)’/or exp Maintenance Therapy/
6. limit 5 to humans
7. exp naltrexone/
8. limit 7 to humans
9. exp Maintenance Therapy/or exp Naloxone/or exp Drug Therapy/or exp Drug Dependency/or exp Heroin Addiction/
10. limit 7 to humans
11. exp Treatment Outcomes/or exp Clinical Trials/or exp Drug Therapy/or exp Heroin Addiction/or exp Methadone Maintenance/
12. limit 9 to humans
13. 2 and 8 and 10
14. 2 and 10
15. 2 and 12
16. 2 and 6 and 12
17. 13 or 14 or 15 or 16
Cochrane library search strategy search = __ 1. search title, abstract, keywords: methadone
2. search title, abstract, keywords: buprenorphine
3. search title, abstract, keywords: naltrexone
4. search title, abstract, keywords: heroin assisted treatment
Clinical Trials Registry through National Institutes for Health search strategy Search = ____ ‘methadone’ OR ‘suboxone’ OR ‘Buprenorphine’ OR ‘substitute opioid therapy’ OR ‘naltrexone’ OR ‘heroin assisted treatment’ OR ‘heroin adjustment therapy’ AND ‘opioid addiction’, with additional criteria including: Completed studies, exclude unknown status, adult age requirements, and all trials had to be listed as Phase 3, 4
Cochrane Central Register of Controlled Trials search strategy Search = ____ ‘substitute opioid therapy’ OR ‘methadone’ OR ‘naltrexone’ OR ‘buprenorphine’ OR ‘heroin assisted treatment’ OR ‘heroin adjustment therapy’ in title abstract keywords and opioid addiction in title abstract keywords in Trials