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Table 4 Eligibility criteria and screening matrix

From: Study protocol: systematic review and meta-analysis of randomized controlled trials in first-line treatment of squamous non-small cell lung cancer

Eligibility criteria
Patients Male or female patients with histologically or cytologicallyconfirmed squamous NSCLC
  Study participants must have not received chemotherapy treatment prior to first-line chemotherapy for NSCLC at the time of randomization in the study
Interventions The study assesses a chemotherapy treatment in each of the study arms
  No limits are placed on the type of chemotherapy used
Outcomes One or more of the following outcomes must be quantitatively reported in the publication: overall survival, progression-free survival, toxicity, or quality of life
  At least one of the required outcome variables must be reported separately for patients with advanced or metastatic (stage III/IV) NSCLC that is of squamous histology
Study design RCTs
Time frame 1995 to present
Ineligibility criteria
Interventions Not first-line treatment with first-line defined as patients with no prior exposure to chemotherapy
  Radiation therapy in the absence of concurrent chemotherapy in any treatment group
Study design Review articles, news, editorials, commentaries
Time frame Publication date prior to 1995
Matrix for patients with "squamous histology"
Squamous inclusion obvious in abstract? Squamous results obvious in abstract? Inclusion Comments
Yes Yes Yes  
No Yes Yes  
Yes No Yes/No Need full text to determine the inclusion
No No Yes/No Need full text to determine the inclusion
Only non-squamous inclusion obvious in abstract? Squamous results obvious in abstract? Inclusion Comments
Yes Yes Not possible case  
No Yes Yes  
Yes No No  
No No Yes/No Need full text to determine the inclusion
Abstract mentions just NSCLC as inclusion? Squamous results obvious in abstract? Inclusion Comments
Yes Yes Yes  
No Yes Yes/No This may be multisite cancer study, need full text to determine the inclusion
Yes No Yes/No Need full text to determine the inclusion
No No Noise in the search Need full text to determine the inclusion
Multiple cancers If mentions lung cancer Yes/No Need full text to determine the inclusion
  If does not mention any specific tumor types Yes/No Need full text to determine the inclusion
  If only mentions breast cancer or other types and does not mention lung cancer Noise in the search  
Matrix for "not first-line treatment"
Condition Line of treatment to be considered Inclusion Comments
Naïve NSCLC patients 1st Yes  
First- or front-line treatment 1st Yes  
Untreated NSCLC patients 1st Yes  
Metastatic chemo-naïve NSCLC patients 1st Yes  
Chemo-naïve NSCLC patients 1st Yes  
Second-line treatment 2nd No  
(Rx)-resistant NSCLC patients 2nd No  
Recurrent or progressive disease 2nd No  
(Rx)-responder/non-responder patients 2nd No  
If no clear information on line of treatment NA Yes/No Need full text to determine the inclusion