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Table 2 Embase search strategy
| Embase search | |||
|---|---|---|---|
| Category | Search | Query | Hits |
| Design terms | #1 | "randomized controlled trial (topic)"/exp | 37,931 |
| #2 | "randomized controlled trial"/exp | 337,523 | |
| #3 | "randomization"/exp | 61,698 | |
| #4 | "double blind procedure"/exp | 115,032 | |
| #5 | [controlled clinical trial]/lim | 511,199 | |
| #6 | [randomized controlled trial]/lim | 337,523 | |
| #7 | "clinical trial"/exp | 961,450 | |
| #8 | "clinical trial (topic)"/exp | 73,222 | |
| #9 | #1 OR #2 OR #3 OR #4 OR #5 OR #6 | 1,088,520 | |
| #10 | singl*: ab,ti OR doubl*: ab,ti OR treb*: ab,ti OR tripl*: ab,ti AND (blind*: ab,ti OR mask*: ab,ti) | 174,394 | |
| #11 | "placebo"/exp | 236,244 | |
| #12 | random* AND (clinical OR control*) AND trial OR (placebo* AND ("randomly allocated" OR (allocated AND random*))) | 504,649 | |
| #13 | (#7 OR #8) AND (#10 OR #11 OR #12) | 513,722 | |
| #14 | #9 OR #13 | 705,098 | |
| Exclusion terms | #15 | [conference review]/lim | 3,863 |
| #16 | "case report":ab,ti | 256,868 | |
| #17 | [review]/lim | 2,026,389 | |
| #18 | [letter]/lim | 827,115 | |
| #19 | "phase 1 clinical trial"/exp | 24,619 | |
| #20 | [short survey]/lim OR "historical article": ab,ti | 514,714 | |
| #21 | "systematic review": ab,ti | 78,920 | |
| #22 | "clinical review": ab,ti | 3,904 | |
| #23 | #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 | 3,628,070 | |
| #24 | #14 NOT #23 | 424,301 | |
| Rx terms | #25 | "drug therapy"/exp/mj | 574,153 |
| #26 | "treatment response"/exp/mj | 2,763 | |
| #27 | "treatment outcome"/exp/mj | 28,936 | |
| #28 | "drug efficacy"/exp/mj | 153,753 | |
| #29 | "outcome assessment"/exp/mj | 9,603 | |
| #30 | chemothera* OR ("drug"/exp/mj AND thera*) OR antineoplastic* OR palliat* OR standar* NEAR/2 care OR support* NEAR/2 care OR "best supportive care" OR best?support* NEXT/2 care | 1,895,030 | |
| #31 | "radiotherapy"/exp | 367,367 | |
| #32 | #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 | 2,609,134 | |
| #33 | #23 AND #31 | 88,937 | |
| Disease terms | #34 | ((lung$ OR pulmon$) NEAR/5 (adenocarcinom$ OR squamous OR "large cell" OR "non-small cell")): ab,ti | 44,817 |
| #35 | "lung non small cell cancer"/exp | 52,027 | |
| #36 | metastatic: ab,ti | 181,820 | |
| #37 | advanced: ab,ti | 320,393 | |
| #38 | stage 3: ab,ti | 61 | |
| #39 | "Stage 3": ab,ti | 8,708 | |
| #40 | stage 4: ab,ti | 32 | |
| #41 | "stage 4": ab,ti | 5,270 | |
| #42 | stage iii: ab,ti | 30 | |
| #43 | "stage iii": ab,ti | 31,468 | |
| #44 | stage iv: ab,ti | 41 | |
| #45 | "stage iv": ab,ti | 20,205 | |
| #46 | "stage iii/iv": ab,ti | 6 | |
| #47 | "stage iii/iv": ab,ti | 4,552 | |
| #48 | "stage iiib/iv": ab,ti | 2 | |
| #49 | "stage iii/iva": ab,ti | 1 | |
| #50 | stage* iii: ab,ti | 32 | |
| #51 | stage* iii*: ab,ti | 49 | |
| #52 | stage* iv: ab,ti | 41 | |
| #53 | stage* iv*: ab,ti | 52 | |
| #54 | stage iii*: ab,ti | 47 | |
| #55 | stage iv*: ab,ti | 46 | |
| #56 | inoperable: ab,ti | 12,989 | |
| #57 | in* operable: ab,ti | 13,465 | |
| #58 | unresectable: ab,ti | 15,735 | |
| #59 | non* resectable: ab,ti | 1,208 | |
| #60 | late* stage: ab,ti | 84 | |
| #61 | late: ab,ti AND stage: ab,ti | 41,346 | |
| #62 | metast*: ab,ti OR advance*: ab,ti | 900,959 | |
| #63 | relaps* OR recurr* OR unresect* OR non?resect* OR in?operable OR non?operable OR un?operable OR advanc* OR metasta* OR late NEAR/2 stage | 1,895,338 | |
| #64 | #34 OR #35 | 61,621 | |
| #65 | #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 OR #54 OR #55 OR #56 OR #57 OR #58 OR #59 OR #60 OR #61 OR #62 OR #63 | 1,943,775 | |
| #66 | #64 AND #65 | 33,907 | |
| #67 | #33 AND #66 | 2,689 | |
| Language and year | #68 | [1995–2013]/py AND [english]/lim | 12,998,680 |
| Final | #69 | #67 AND #68 | 2,901 |
