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Table 1 Key methodological developments in Cochrane Reviews

From: Cochrane methods - twenty years experience in developing systematic review methods

2014 ‘Risk of bias’ tool extension for non standard randomized studies (for example, crossover and cluster trials) and non-randomized studies
2012 Introduction of the Methodological Expectations of Cochrane Intervention Reviews (MECIR) standards
2011 Launch of the Cochrane Methods Innovation fund
2008 Release of version 5 of RevMan incorporating ‘Risk of Bias’ tool
  Grade profiler software (GRADEpro) introduced for ‘Summary of findings’ tables in RevMan
2002 I2 statistics measuring inconsistency in meta-analysis [22]
1996 Launch of The Cochrane Library launched by Update Software incorporating The Cochrane Database of Systematic Reviews, The Database of Abstracts of Reviews of Effectiveness, The Cochrane Controlled Trials Register and The Cochrane Review Methodology Database
  Bias assessment classification system introduced for allocation concealment [27]
1994 First publication demonstration of The Cochrane Database of Systematic Reviews
  Publication of the first edition of the Cochrane Handbook[26]
  Registration of the first Methods Groups: Statistical MG and Individual Patient Data MG
1993 Formal launch of the Cochrane Collaboration at the first Cochrane Colloquium in Oxford, UK
  Release of version 1 of Review Manager (RevMan)
1992 Formal launch of the first UK Cochrane Centre in Oxford
1988 Publication of the first in a series of overviews (meta-analyses) in the British Journal of Obstetrics and Gynaecology
1976 Term ‘meta-analysis’ first introduced [25]
1972 Publication of Archie Cochrane’s Effectiveness and Efficiency: Random Reflections on Health Services which first drew attention to the collective ignorance about the effects of health care [1]